Lomustine is used to treat brain tumors in people who have already received surgery or radiation.

Lomustine is also used with other cancer medicines to treat Hodgkin's disease, after other treatments have failed.

Lomustine may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• bone marrow suppression;
• liver disease;
• kidney disease; or
• lung disease or breathing problems.

Using lomustine may increase your risk of developing other types of cancer, such as leukemia. Ask your doctor about your specific risk.

Lomustine can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, do not use lomustine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3.5 months (14 weeks) after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using lomustine.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because lomustine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Use Ceenu (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• jaundice (yellowing of the skin or eyes);
• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
• kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
• signs of infection--fever, chills, sore throat, blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
• late-onset lung damage--new or worsening cough, chest pain, shortness of breath (may develop as long as 6 months or later after you take lomustine).

Common side effects may include:

• nausea, vomiting;
• delayed infection;
• mouth sores; or
• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.