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Home > Drugs > Phenothiazine antiemetics > Chlorpromazine
Phenothiazine antiemetics

Chlorpromazine

https://themeditary.com/drug/chlorpromazine-7913.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 16, 2023  Additional Content by TheMediTary.Com

Generic name: chlorpromazine (oral/injection) [ klor-proe-ma-zeen ]

Drug class: Phenothiazine antiemetics, Phenothiazine antipsychotics

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Chlorpromazine (Chlorpromazine (oral/injection) [ klor-proe-ma-zeen ])-GG 455 10-10 mg-Brown-Round Chlorpromazine 10 mg (GG 455 10)
  • Chlorpromazine (Chlorpromazine (oral/injection) [ klor-proe-ma-zeen ])-GG 407 50-50 mg-Brown-Round Chlorpromazine 50 mg (GG 407 50)
  • Chlorpromazine (Chlorpromazine (oral/injection) [ klor-proe-ma-zeen ])-GG 437 100-100 mg-Brown-Round Chlorpromazine 100 mg (GG 437 100)
  • Chlorpromazine (Chlorpromazine (oral/injection) [ klor-proe-ma-zeen ])-GG 457 200-200 mg-Brown-Round Chlorpromazine 200 mg (GG 457 200)
  • View all images

What is Chlorpromazine?

Chlorpromazine is a phenothiazine (FEEN-oh-THYE-a-zeen) that is used to treat psychotic disorders such as schizophrenia or manic-depression in adults.

Chlorpromazine is also used in adults to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

In children ages 1 through 12 years, chlorpromazine is used to treat severe behavioral problems (such as combative or explosive behavior) or hyperactivity with excessive motor activity.

Chlorpromazine may also be used for purposes not listed in this medication guide.

Warnings

Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Chlorpromazine is not approved for use in older adults with dementia-related psychosis.

How should I take Chlorpromazine

Chlorpromazine comes as a tablet to take by mouth. Chlorpromazine is usually taken two to four times a day. When chlorpromazine is used to control nausea and vomiting, it is usually taken every 4-6 hours as needed. When chlorpromazine is used to relieve nervousness before surgery, it is usually taken 2-3 hours before surgery. When chlorpromazine is used to relieve hiccups, it is usually taken 3-4 times a day for up to 3 days or until the hiccups stop. If the hiccups do not stop after 3 days of treatment, a different medication should be used. If you are taking chlorpromazine on a regular schedule, take it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take chlorpromazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of chlorpromazine and gradually increase your dose. Your doctor may decrease your dose once your condition is controlled. Be sure to tell your doctor how you are feeling during your treatment with chlorpromazine.

If you are taking chlorpromazine to treat schizophrenia or another psychotic disorder, chlorpromazine may control your symptoms but will not cure your condition. Continue to take chlorpromazine even if you feel well. Do not stop taking chlorpromazine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking chlorpromazine, you may experience withdrawal symptoms, such as nausea, vomiting, stomach pain, dizziness, and shakiness.

Dosing information

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Chlorpromazine oral is taken by mouth.

Chlorpromazine injection is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection.

You may be asked to lie down for a short time after you receive a chlorpromazine injection. This medicine can lower your blood pressure and you may feel light-headed after an injection.

Your doctor will need to check your progress on a regular basis. Your vision may also need to be checked.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorpromazine.

If you need to have a spinal tap (lumbar puncture) or any type of x-ray scan or MRI of your spinal cord, tell the doctor ahead of time that you are using chlorpromazine.

Do not stop using chlorpromazine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

Detailed Chlorpromazine dosage information
Chlorpromazine Dosage information (more detail)

Before Taking

You should not use chlorpromazine if you are allergic to chlorpromazine or other phenothiazines (such as fluphenazine, perphenazine, prochlorperazine, promethazine, thioridazine, or trifluoperazine).

Do not use chlorpromazine if you have recently used large amounts of alcohol or medicine that makes you sleepy.

Chlorpromazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

  • severe asthma, emphysema, or other breathing problem;

  • a sulfite allergy;

  • bone marrow suppression;

  • heart disease;

  • liver or kidney disease;

  • breast cancer;

  • glaucoma;

  • Parkinson's disease;

  • seizures;

  • a blockage in your intestines;

  • a brain tumor; or

  • pheochromocytoma (tumor of the adrenal gland).

Tell your doctor if you will be exposed to extreme heat, or to insecticide poisons while you are using chlorpromazine.

Do not give this medicine to a child without medical advice. Talk with your doctor before giving chlorpromazine to a child who has been ill with a fever or flu symptoms.

Using antipsychotic medicine in the last 3 months of pregnancy may cause medical problems, breathing problems, feeding problems, or withdrawal symptoms in the newborn. However, you may have withdrawal symptoms or other problems if you stop using your medicine during pregnancy. If you get pregnant, tell your doctor right away. Do not stop using chlorpromazine without your doctor's advice.

You should not breast-feed while using this medicine.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, bloating or stomach cramps, feeling restless, fever, muscle stiffness, jerky muscle movements, changes in heart rate, fainting, or seizure (convulsions).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Chlorpromazine?

Avoid driving or hazardous activity until you know how chlorpromazine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

Avoid exposure to sunlight or tanning beds. Chlorpromazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Chlorpromazine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Long-term use of chlorpromazine can cause a serious movement disorder that may not be reversible. The longer you use chlorpromazine, the more likely you are to develop this disorder, especially if you are a an older adult.

Chlorpromazine may cause serious side effects. Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • stiffness in your neck, tightness in your throat, trouble breathing or swallowing;

  • a light-headed feeling, like you might pass out;

  • confusion, agitation, feeling jittery, trouble sleeping;

  • weakness;

  • breast swelling or discharge;

  • a seizure;

  • jaundice (yellowing of the skin or eyes);

  • low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Some side effects may be more likely in older adults.

Common side effects of chlorpromazine may include:

  • drowsiness;

  • dry mouth or stuffy nose;

  • blurred vision;

  • constipation; or

  • impotence, trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Chlorpromazine Side Effects

What other drugs will affect Chlorpromazine?

Using chlorpromazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect chlorpromazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor and your eye doctor. You should have regularly scheduled eye exams during your treatment with chlorpromazine because chlorpromazine may cause eye disease.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking chlorpromazine.

Chlorpromazine may interfere with the results of home pregnancy tests. Talk to your doctor if you think you might be pregnant during your treatment with chlorpromazine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Chlorpromazine (Chlorpromazine (oral/injection) [ klor-proe-ma-zeen ])

Dosage information
Chlorpromazine Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Phenothiazine antiemetics

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Mania
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