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Home > Drugs > Anticoagulant reversal agents > Coagulation factor xa
Anticoagulant reversal agents

Coagulation factor xa

https://themeditary.com/drug/coagulation-factor-xa-6604.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 14, 2023  Additional Content by TheMediTary.Com

Generic name: coagulation factor xa [ koe-ag-ue-lay-tion-fak-tor-xa ]

Drug class: Anticoagulant reversal agents

Dosage form: intravenous powder for injection (recombinant, inactivated-zhzo 200 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Andexxa, Factor xa (recombinant), inactivated-zhzo (monograph)

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Coagulation factor xa?

Coagulation factor Xa is a protein that reverses the effects of certain anticoagulant medications that are used to treat or prevent blood clots. Reversing anticoagulant medicine is necessary if you have uncontrolled or life-threatening bleeding as a result of how that medicine works.

Coagulation factor Xa is used to treat uncontrolled bleeding in people who take the anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis).

Coagulation factor Xa was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, healthy volunteers responded to coagulation factor Xa, but further studies are needed.

Coagulation factor Xa may also be used for purposes not listed in this medication guide.

Warnings

coagulation factor Xa is used to reverse the effects of anticoagulant medication, which may increase your risk of a blood clot, heart attack, stroke, or death. Watch for symptoms such as chest pain, sudden numbness or weakness, problems with vision or speech, and swelling or redness in an arm or leg.

How should I take Coagulation factor xa

Coagulation factor Xa is given as an infusion into a vein. A healthcare provider will give you this injection.

coagulation factor Xa must be given slowly, and the infusion can take at least 2 hours to complete.

Once your bleeding has been controlled, you may need to begin using anticoagulant medication again to prevent future blood clots. Follow your doctor's instructions very carefully.

Dosing information

Usual Adult Dose for Reversal of Anticoagulation:

Reversal of Apixaban Anticoagulation:
Last apixaban dose was 5 mg or less: 400 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 4 mg/min IV infusion for up to 120 minutes

Last apixaban dose was greater than 5 mg (or unknown) and was administered less than 8 hours (or unknown) ago: 800 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 8 mg/min IV infusion for up to 120 minutes

Last apixaban dose was greater than 5 mg (or unknown) and was administered at least 8 hours ago: 400 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 4 mg/min IV infusion for up to 120 minutes

Comments: Resume anticoagulant therapy as soon as medically appropriate following treatment with this drug.

Use: Reversal of anticoagulation in patients who have been treated with apixaban and are experiencing life-threatening or uncontrolled bleeding.


Reversal of Rivaroxaban Anticoagulation:
Last rivaroxaban dose was 10 mg or less: 400 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 4 mg/min IV infusion for up to 120 minutes

Last rivaroxaban dose was greater than 10 mg (or unknown) and was administered less than 8 hours (or unknown) ago: 800 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 8 mg/min IV infusion for up to 120 minutes

Last rivaroxaban dose was greater than 5 mg (or unknown) and was administered at least 8 hours ago: 400 mg IV bolus at a target rate of 30 mg/min, followed within 2 minutes later by 4 mg/min IV infusion for up to 120 minutes

Comments: Resume anticoagulant therapy as soon as medically appropriate following treatment with this drug.

Use: Reversal of anticoagulation in patients who have been treated with rivaroxaban and are experiencing life-threatening or uncontrolled bleeding.

Detailed Coagulation factor Xa dosage information
Coagulation factor xa Dosage information (more detail)

Before Taking

You should not be treated with coagulation factor Xa if you have had an allergic reaction to clotting factor medicine.

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.

In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

What happens if I miss a dose?

Because you will receive coagulation factor Xa in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Coagulation factor xa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Coagulation factor xa side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Coagulation factor Xa may cause serious side effects. Call your doctor at once if you have:

  • pain or burning when you urinate;

  • cough with mucus, chest pain, and shortness of breath;

  • fever, chills; or

  • continued bleeding after treatment.

Reversing the effects of anticoagulant medication may increase your risk of a blood clot, heart attack, stroke, or death. Get emergency medical help if you have any of these symptoms after being treated with coagulation factor Xa, especially if you have not started taking anticoagulant medication again:

  • signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg; or

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Common side effects of coagulation factor Xa may include:

  • lung problems;

  • painful urination; or

  • pain, swelling, burning, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Coagulation factor xa Side Effects

What other drugs will affect Coagulation factor xa?

Other drugs may affect coagulation factor Xa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about Coagulation factor xa (Coagulation factor xa [ koe-ag-ue-lay-tion-fak-tor-xa ])

Dosage information
Coagulation factor xa Side Effects
During pregnancy
Drug images
Side effects
Drug class: Anticoagulant reversal agents

Patient resources

Andexanet Alfa

Related treatment guides

Reversal of Anticoagulation
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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