Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) that is used in adults to treat signs and symptoms of osteoarthritis or rheumatoid arthritis. Oxaprozin is also used to treat rheumatoid arthritis in children at least 6 years old.

Oxaprozin may also be used for purposes not listed in this medication guide.

Oxaprozin can increase your risk of fatal heart attack or stroke.Oxaprozin may also cause stomach or intestinal bleeding, which can be fatal. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). This can occur without warning, especially in older adults.

Tell your doctor if you have or ever had:

You should not take oxaprozin if you are allergic to it, or if you have ever had an asthma attack, hives, or a severe allergic reaction (sneezing, runny or stuffy nose, wheezing) after taking aspirin or another NSAID.

It may be harder for you to get pregnant while you are using this medicine.

Do not use oxaprozin during pregnancy unless your doctor tells you to. Using an NSAID in the last 20 weeks can harm the unborn baby or cause pregnancy complications.

Ask a doctor if it is safe to breastfeed while using this medicine.

• congestive heart failure, heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
• a heart attack, stroke, or blood clot;
• stomach ulcers or bleeding;
• asthma;
• fluid retention;
• liver disease; or
• kidney disease (or if you are on dialysis).

Use Coxanto (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have (sneezing, runny or stuffy nose; wheezing, trouble breathing, hives, swelling of your face, lips, tongue, or throat) or (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). signs of an allergic reaction:a severe skin reaction

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Get emergency medical help if you have chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, or feeling short of breath. signs of a heart attack or stroke:

Stop using oxaprozin and call your doctor at once if you have:

• any skin rash, no matter how mild, or a patchy skin color that worsens in sunlight;
• flu-like symptoms;
• severe headache, blurred vision, pounding in your neck or ears;
• heart problems--swelling, rapid weight gain, feeling short of breath;
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• liver problems--diarrhea, loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• kidney problems--swelling, urinating less, feeling tired or short of breath;
• high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
• low red blood cells (anemia)--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet.

• nausea, upset stomach;
• diarrhea, constipation; or
• rash.

Oxaprozin may worsen asthma attacks in people who have asthma. Talk with your doctor about your own risk.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid drinking alcohol and smoking, since it can increase your risk of stomach bleeding.

Avoid taking aspirin or other NSAIDs unless your doctor tells you to.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to oxaprozin (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Oxaprozin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.