Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Cyproheptadine is used to treat sneezing, runny nose, itching, red or watery eyes, and other symptoms of seasonal allergies (hay fever). Cyproheptadine is also used to treat other conditions such as eczema or skin reactions to insect bites.

Cyproheptadine is sometimes used to treat certain types of headaches, including migraines.

Cyproheptadine may also be used for purposes not listed in this medication guide.

You should not use cyproheptadine if you have narrow-angle glaucoma, a stomach ulcer or obstruction, an enlarged prostate, urination problems, or if you are having an asthma attack. You also should not use cyproheptadine if you are breast-feeding a baby, if you are elderly, or if you have a debilitating disease.

Do not use cyproheptadine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

You should not use antihistamine medication to make a child sleepy.

Cyproheptadine comes as a tablet and a solution (liquid) to take by mouth. It is usually taken two or three times a day. Take cyproheptadine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cyproheptadine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are using the solution, do not use a household spoon to measure your dose. Use the measuring cup or spoon that came with the medication or use a spoon that is made especially for measuring medication.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use cyproheptadine in larger or smaller amounts or for longer than recommended.

Do not give this medicine to a child younger than 2 years old. You should not use antihistamine medication to make a child sleepy. Death can occur from the misuse of an antihistamine in very young children.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Tell your doctor if you have any changes in weight. Cyproheptadine doses are based on weight (especially in children and teenagers), and any changes may affect the dose.

This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking cyproheptadine.

Store in a tightly-closed container at room temperature, away from moisture and heat.

You should not use cyproheptadine if you are allergic to it, or if:

• you have narrow-angle glaucoma;

• you have a stomach ulcer or obstruction;

• you have an enlarged prostate or urination problems;

• you are breast-feeding a baby;

• you are having an asthma attack; or

• you are elderly or have a debilitating disease.

Do not give this medicine to a newborn or premature baby. Cyproheptadine is not approved for use by anyone younger than 2 years old.

To make sure cyproheptadine is safe for you, tell your doctor if you have:

• glaucoma;

• a history of asthma;

• high blood pressure;

• heart disease; or

• an overactive thyroid.

Cyproheptadine is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether cyproheptadine passes into breast milk or if it could harm a nursing baby. Antihistamines may slow breast milk production. You should not breast-feed while using this medicine.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, hallucinations, very dry mouth, dilated pupils, pale or reddish skin, tingly feeling, vomiting, restlessness (in a child), weak or shallow breathing, or a seizure (convulsions).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unless your doctor tells you otherwise, continue your normal diet.

cyproheptadine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol with this medicine can cause side effects.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cyproheptadine may cause serious side effects. Stop using cyproheptadine and call your doctor at once if you have:

• a light-headed feeling, like you might pass out;

• tremor, seizure (convulsions);

• confusion, hallucinations;

• little or no urination;

• fast or pounding heartbeats;

• easy bruising or bleeding;

• ringing in your ears; or

• pale or yellowed skin, dark colored urine, fever, weakness.

Common side effects of cyproheptadine may include:

• drowsiness, dizziness;

• dry mouth, nose, or throat;

• constipation;

• blurred vision; or

• feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Taking cyproheptadine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with cyproheptadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

You might feel drowsy when taking cyproheptadine. Let your doctor know if your side effects are severe or interfere with your daily life.

Your dosage of cyproheptadine will depend on your medical condition, your age, and other factors.

Follow the instructions on your prescription label carefully when using this medicine.

Cyproheptadine is sometimes used to treat other conditions, including:

• Cushing’s Syndrome (a condition caused by excess hormones)
• Migraine headaches
• Spasticity
• Cyclical vomiting syndrome