Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.

Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.

Donepezil and memantine is a combination medicine used to treat moderate to severe dementia of the Alzheimer's type.

Donepezil and memantine is not a cure for Alzheimer's disease. This condition will progress over time, even in people who take donepezil.

Donepezil and memantine may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to donepezil or memantine.

To make sure donepezil and memantine is safe for you, tell your doctor if you have:

• asthma or other breathing disorder;
• heart disease, or heart rhythm disorder;
• a history of seizures;
• stomach ulcer, or a history of stomach or intestinal bleeding;
• bladder obstruction or other urination problems;
• liver disease; or
• kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether donepezil and memantine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Use Donepezil And Memantine (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• severe or ongoing vomiting;
• a light-headed feeling, like you might pass out;
• slow heartbeats;
• seizure (convulsions);
• painful or difficult urination;
• new or worsening breathing problems; or
• signs of stomach bleeding--severe heartburn or stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

• nausea, vomiting, diarrhea, loss of appetite;
• headache;
• dizziness; or
• easy bruising.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.