Doravirine, lamivudine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Doravirine, lamivudine, and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Doravirine, lamivudine, and tenofovir may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to doravirine, lamivudine, or tenofovir.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with doravirine, lamivudine, and tenofovir. Your doctor may change your treatment plan if you have used any of the following medicines in the past 4 weeks:

• enzalutamide;
• mitotane;
• rifampin;
• rifapentine;
• St. John's wort; or
• seizure medicine--carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.

Tell your doctor if you have ever had:

• hepatitis B;
• kidney disease; or
• bone problems (including a broken bone, or osteoporosis).

You may be more likely to have a broken bone while using doravirine, lamivudine, and tenofovir. Talk with your doctor about ways to keep your bones healthy.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

This medicine is not approved for use by anyone younger than 18 years old.

Use Doravirine, Lamivudine, And Tenofovir (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• urinating more or less than usual;
• increased thirst;
• new or worsening bone pain;
• muscle pain or weakness; or
• pain in your arms, legs, hands, or feet.

Doravirine, lamivudine, and tenofovir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

• signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
• trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
• swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects may include:

• nausea;
• dizziness; or
• strange dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.