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Home > Drugs > Group III antiarrhythmics > Dronedarone
Group III antiarrhythmics

Dronedarone

https://themeditary.com/drug/dronedarone-7439.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Aug 15, 2023  Additional Content by TheMediTary.Com

Generic name: dronedarone [ droe-ne-da-rone ]

Drug class: Group III antiarrhythmics

Dosage form: oral tablet (400 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Multaq

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Dronedarone?

Dronedarone is a heart rhythm medicine that helps lower your risk of needing to be hospitalized for a heart rhythm disorder called atrial fibrillation. Dronedarone is for adults who have had this disorder in the past, but now have normal heart rhythm.

Dronedarone may also be used for purposes not listed in this medication guide.

Warnings

Dronedarone can double your risk of death if you have certain heart conditions. Call your doctor at once if you have an irregular pulse, chest tightness, wheezing, a cough with foamy mucus, swelling or rapid weight gain, or trouble breathing (especially at night).

Tell your doctor about all other medicines you start or stop using. Many drugs can interact, and some drugs should not be used together.

Dronedarone can also cause liver problems. Call your doctor if you have symptoms such as vomiting, loss of appetite, right-sided upper stomach pain, dark urine, and yellowing of your skin or eyes.

How should I take Dronedarone

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Dronedarone is usually taken with morning and evening meals.

Your heart function may need to be checked every 3 months to help determine if you still need dronedarone. Do not stop taking dronedarone without your doctor's advice.

Check your pulse often, and call your doctor if you notice an irregular rhythm.

Store at room temperature away from heat and moisture.

Dosing information

Usual Adult Dose for Atrial Fibrillation:

400 mg orally 2 times a day with a meal

Use: To reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL), with a recent episode of AF/AFL and associated cardiovascular risk factors (i.e., age greater than 70 years, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter 50 mm or more, or left ventricular ejection fraction [LVEF] less than 40%), who are in sinus rhythm or who will be cardioverted.

Usual Adult Dose for Atrial Flutter:

400 mg orally 2 times a day with a meal

Use: To reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL), with a recent episode of AF/AFL and associated cardiovascular risk factors (i.e., age greater than 70 years, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter 50 mm or more, or left ventricular ejection fraction [LVEF] less than 40%), who are in sinus rhythm or who will be cardioverted.

Detailed Dronedarone dosage information
Dronedarone Dosage information (more detail)

Before Taking

You should not use dronedarone if you are allergic to it, or if you have:

  • severe liver disease;

  • a serious heart condition such as "sick sinus syndrome," "AV block" (unless you have a pacemaker), or very slow heartbeats that have caused you to faint;

  • if you are pregnant or breastfeeding; or

  • if you used a medicine called amiodarone and then had lung problems or liver problems.

Dronedarone can double your risk of death if you have certain heart conditions. You should not use dronedarone if:

  • you have severe heart failure;

  • you were recently hospitalized for worsening heart failure symptoms (shortness of breath, chest tightness, night-time breathing problems, swelling, rapid weight gain); or

  • you have a "permanent" atrial fibrillation that cannot be changed back to a normal rhythm (this will be determined by your doctor).

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with dronedarone. Your doctor may change your treatment plan if you also use:

  • other heart rhythm medicines;

  • cyclosporine;

  • ritonavir or other antiviral medicine;

  • an antibiotic such as clarithromycin or telithromycin;

  • an antidepressant such as amitriptyline, clomipramine, doxepin, imipramine, nefazodone, and others;

  • antifungal medicine such as itraconazole, ketoconazole, or voriconazole; or

  • antipsychotic medicine such as chlorpromazine, fluphenazine, promethazine, thioridazine, and others.

Tell your doctor if you have other heart problems.

Dronedarone may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using dronedarone.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Dronedarone?

Grapefruit may interact with dronedarone and cause side effects. Avoid consuming grapefruit while taking dronedarone.

Dronedarone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dronedarone may cause serious side effects. Call your doctor at once if you have:

  • dry cough, shortness of breath;

  • little or no urination;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • heart problems--swelling, rapid weight gain, feeling short of breath;

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, jaundice (yellowing of the skin or eyes); or

  • low magnesium or potassium levels--dizziness, numbness or tingling, irregular heartbeats, fluttering in your chest, increased thirst or urination, muscle cramps or limp feeling.

Common side effects of dronedarone may include:

  • stomach pain, indigestion, nausea, vomiting, diarrhea;

  • feeling weak or tired; or

  • skin rash, itching, or redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Dronedarone Side Effects

What other drugs will affect Dronedarone?

Dronedarone can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your current medicines. Many drugs can affect dronedarone, especially:

  • digoxin;

  • St. John's wort;

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • a diuretic or "water pill";

  • medicines to treat tuberculosis;

  • medicine to prevent organ transplant rejection;

  • seizure medicine; or

  • "statin" cholesterol medication (Lipitor, Zocor, Vytorin, and others).

This list is not complete and many other drugs may affect dronedarone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to dronedarone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Dronedarone (Dronedarone [ droe-ne-da-rone ])

Dosage information
Dronedarone Side Effects
During pregnancy
Drug images
Side effects
Drug class: Group III antiarrhythmics

Related treatment guides

Atrial Fibrillation
Atrial Flutter
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