Elranatamab is used to treat adults with multiple myeloma who have received at least 4 treatment regimens and their cancer has returned or did not respond to a previous treatment.

Elranatamab is available only from a certified pharmacy under a special program.

Elranatamab may also be used for purposes not listed in this medication guide.

Tell your doctor if you have or have ever had:

• low white blood cell (WBC) counts;
• an active or recent infection; or
• abnormal liver function tests.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using elranatamab and for at least 4 months after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 4 months after your last dose.

Use Elranatamab (Subcutaneous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers if you have signs of cytokine release syndrome (CRS), a serious side effect: fever, chills, trouble breathing, confusion, severe vomiting or diarrhea, fast or irregular heartbeats, feeling light-headed or very tired.

Also call your doctor right away if you have:

• signs of infection--cold symptoms such as stuffy nose, sneezing, sore throat, fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, chest pain, pain in your side or lower back, painful urination, blood or pus in your urine;
• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough; or
• neurological problems--headache, jerking muscle movements, rigid muscles, feeling restless, numbness and tingling, confusion, problems speaking, muscle spasms, tremors, double vision, changes in handwriting, problems walking, muscle weakness in body or face, hearing loss, burning, throbbing, or stabbing pain.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• bone pain, muscle pain;
• diarrhea, nausea;
• fever, rash, cough;
• loss of appetite;
• pain, bruising, swelling, or irritation where the medicine was injected; or
• tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity for 48 hours after receiving certain doses of this medicine or until neurological symptoms go away. Your reactions could be impaired.