Amitriptyline is a tricyclic antidepressant that is used to treat symptoms of depression.

Amitriptyline may also be used for purposes not listed in this medication guide.

You should not use amitriptyline if you are allergic to it, or:

Tell your doctor if you are pregnant or breastfeeding.

Amitriptyline is not approved for use by anyone younger than 12 years old.

• if you have recently had a heart attack.

• bipolar disorder (manic-depression) or schizophrenia;
• mental illness or psychosis;
• liver disease;
• heart disease;
• a heart attack, stroke, or seizures;
• diabetes (amitriptyline may raise or lower blood sugar);
• glaucoma; or
• problems with urination.

Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Use Endep (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have hives; difficulty breathing; swelling of your face, lips, tongue, or throat. signs of an allergic reaction:

Call your doctor at once if you have:

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg;
• unusual thoughts or behavior;
• a light-headed feeling, like you might pass out;
• chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• pounding heartbeats or fluttering in your chest;
• confusion, hallucinations;
• a seizure (convulsions);
• painful or difficult urination;
• severe constipation;
• easy bruising, unusual bleeding; or
• fever, chills, sore throat, mouth sores.

• constipation, diarrhea;
• nausea, vomiting, upset stomach;
• mouth pain, unusual taste, black tongue;
• appetite or weight changes;
• urinating less than usual;
• itching or rash;
• breast swelling (in men or women); or
• decreased sex drive, impotence, or difficulty having an orgasm.

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with amitriptyline.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid exposure to sunlight or tanning beds. Amitriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.