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Home > Drugs > Multikinase inhibitors > Entrectinib
Multikinase inhibitors

Entrectinib

https://themeditary.com/drug/entrectinib-7988.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 16, 2023  Additional Content by TheMediTary.Com

Generic name: entrectinib [ en-trek-ti-nib ]

Drug class: Multikinase inhibitors

Dosage form: oral capsule (100 mg; 200 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Rozlytrek, Entrectinib (systemic) (monograph)

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Entrectinib?

Entrectinib is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic).

Entrectinib is also used in adults and children at least 12 years old who have solid tumors that have spread or cannot be safely removed with surgery, or when other treatments have failed or are not safe options.

Entrectinib is used only if your cancer has a specific abnormal gene. Your doctor will test you for this gene.

Entrectinib may also be used for purposes not listed in this medication guide.

Warnings

Entrectinib may cause new or worsened symptoms of congestive heart failure. Call your doctor at once if you have swelling in your lower legs, rapid weight gain, cough, wheezing, shortness of breath, or trouble breathing while lying down.

How should I take Entrectinib

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take entrectinib with or without food.

Swallow the capsule whole and do not crush, chew, break, or open it.

If you vomit shortly after taking entrectinib, take another dose.

Store at room temperature away from moisture and heat.

Do not change your dose or stop taking entrectinib without your doctor's advice.

Dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

600 mg orally once a day until disease progression or unacceptable toxicity

Use: For adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are ROS1-positive

Usual Adult Dose for Solid Tumors:

600 mg orally once a day until disease progression or unacceptable toxicity

Uses: For adult patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Usual Pediatric Dose for Solid Tumors:

12 years and older:
-Body surface area (BSA) greater than 1.5 m2: 600 mg orally once a day
-BSA 1.11 to 1.5 m2: 500 mg orally once a day
-BSA 0.91 to 1.1 m2: 400 mg orally once a day

Use: For pediatric patients 12 years and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Detailed Entrectinib dosage information
Entrectinib Dosage information (more detail)

Before Taking

Tell your doctor if you have ever had:

  • gout;

  • heart problems;

  • long QT syndrome (in you or a family member);

  • liver or kidney disease;

  • a nervous system disorder; or

  • problems with your eyes or vision.

You may need to have a negative pregnancy test before starting this treatment.

Entrectinib can harm an unborn baby or cause birth defects if the mother or the father is using entrectinib.

  • If you are a woman, do not use entrectinib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 weeks after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using entrectinib.

Do not breastfeed while using this medicine, and for at least 7 days after your last dose.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not eat grapefruit or drink grapefruit juice while taking this medication.

What should I avoid while using Entrectinib?

Avoid driving or hazardous activity until you know how entrectinib will affect you. Your reactions could be impaired.

Grapefruit may interact with entrectinib and lead to unwanted side effects. Avoid the use of grapefruit products.

Entrectinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Entrectinib may cause serious side effects. Call your doctor at once if you have:

  • bone pain or problems moving;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • nausea, vomiting, loss of appetite, right-sided upper stomach pain;

  • swelling in your lower legs, rapid weight gain;

  • cough, wheezing, shortness of breath, trouble breathing while lying down;

  • confusion, hallucinations, problems with memory or concentration;

  • dizziness, mood changes, trouble sleeping; or

  • blurred vision, double vision, increased sensitivity to light, or seeing flashes of light or "floaters" in your vision.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of entrectinib may include:

  • changes in your mental status;

  • vision changes;

  • nausea, vomiting, diarrhea, constipation;

  • fever, cough;

  • dizziness, tiredness;

  • weight gain, swelling;

  • muscle or joint pain;

  • trouble breathing; or

  • changes in your sense of taste or touch.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Entrectinib Side Effects

What other drugs will affect Entrectinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect entrectinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with entrectinib. Your doctor may order certain lab tests before and during your treatment to check your body's response to entrectinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Entrectinib (Entrectinib [ en-trek-ti-nib ])

Dosage information
Entrectinib Side Effects
During pregnancy
Drug images
Side effects
Drug class: Multikinase inhibitors

Related treatment guides

Solid Tumors
Non-Small Cell Lung Cancer
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