Epcoritamab is used to treat certain types of lymphoma (a cancer of the lymphatic system) in adults whose cancer has returned or did not respond to another treatment and who have received at least two previous cancer treatments.

Epcoritamab may also be used for purposes not listed in this medication guide.

Tell your doctor if you have an infection.

You may need to have a negative pregnancy test before starting this treatment.

May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using epcoritamab and for at least 4 moths after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 4 months after your last dose.

Use Epcoritamab (Subcutaneous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers if you have signs of cytokine release syndrome (CRS), a serious side effect: fever, chills, trouble breathing, confusion, severe vomiting or diarrhea, fast or irregular heartbeats, feeling light-headed or very tired.

Call your doctor at once if you have:

• signs and symptoms of nervous system disorders--confusion, disorientation, muscle weakness, memory problems, tremors, trouble speaking or writing, tiredness, sleepiness, or seizures;
• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
• signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding.

Your treatment with epcoritamab may be temporarily or permanently discontinued if you have certain side effects.

Common side effects may include:

• tiredness;
• bone and muscle pain;
• stomach pain;
• fever;
• nausea, diarrhea; or
• bruising, swelling, warmth, redness, oozing, or bleeding where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.