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Home > Drugs > Recombinant human erythropoietins > Epoetin beta and methoxy polyethylene glycol
Recombinant human erythropoietins

Epoetin beta and methoxy polyethylene glycol

https://themeditary.com/drug/epoetin-beta-and-methoxy-polyethylene-glycol-7991.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 16, 2023  Additional Content by TheMediTary.Com

Generic name: epoetin beta and methoxy polyethylene glycol [ e-poe-e-tin-bay-ta-meth-ox-ee-pol-ee-eth-il-een-glye-kol ]

Drug class: Recombinant human erythropoietins

Dosage form: injectable solution (100 mcg/0.3 ml; 150 mcg/0.3 ml; 200 mcg/0.3 ml; 30 mcg/0.3 ml; 50 mcg/0.3 ml; 75 mcg/0.3 ml)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Mircera, Methoxy polyethylene glycol-epoetin beta (systemic) (monograph)

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Epoetin beta and methoxy polyethylene glycol?

Epoetin beta and methoxy polyethylene glycol is a combination medicine used to treat anemia (lack of red blood cells) and to reduce the need for blood cell transfusions.

Epoetin beta and methoxy polyethylene glycol is used to treat anemia caused by chronic kidney disease in adults, or in children at least 5 years old who are on hemodialysis.

epoetin beta and methoxy polyethylene glycol is not for treating anemia caused by cancer chemotherapy. Epoetin beta and methoxy polyethylene glycol may increase tumor growth or decrease survival time in people with certain types of cancer.

Epoetin beta and methoxy polyethylene glycol should not be used to take the place of an emergency blood cell transfusion.

Epoetin beta and methoxy polyethylene glycol may also be used for purposes not listed in this medication guide.

Warnings

You should not use epoetin beta and methoxy polyethylene glycol if you have uncontrolled high blood pressure or if you have ever had pure red cell aplasia.

This medicine is not for treating anemia caused by cancer chemotherapy.

This medicine can increase your risk of serious or fatal side effects, including heart attack, stroke, or blood clot. Call your doctor or get emergency medical help if you have symptoms such as: chest pain, trouble breathing, sudden numbness or weakness, a cold or pale arm or leg, confusion, or problems with speech or balance.

How should I take Epoetin beta and methoxy polyethylene glycol

epoetin beta and methoxy polyethylene glycol is usually given once every 2 weeks or once per month. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Epoetin beta and methoxy polyethylene glycol is injected under the skin or given as an infusion into a vein. When used in a child, the medicine should be given only into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Your blood pressure will need to be checked often. You will also need frequent medical tests, and your next dose may be delayed based on the results.

Call your doctor if you have signs that your body is not responding to this medicine (pale skin, unusual tiredness, lack of energy, dizziness, fainting).

Your doctor may have you take an iron supplement. Take only the type and amount your doctor prescribes.

If you need surgery, tell your surgeon you currently use epoetin beta and methoxy polyethylene glycol. You may need to take medicine to prevent blood clots for a short time after your surgery.

Store prefilled syringes in the refrigerator. Do not freeze or shake. Keep the medicine in the original container until you are ready to give an injection.

You may also store a prefilled syringe at cool room temperature, but you must use the syringe within 30 days or throw it away. Protect from light.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Dosing information

Usual Adult Dose for Anemia Associated with Chronic Renal Failure:

Patients NOT on Dialysis:

Not currently on erythropoiesis-stimulating agents (ESAs):
Initial dose: 0.6 mcg/kg, intravenously (IV) or subcutaneously (SC), once every 2 weeks
Maintenance dose (when hemoglobin is stabilized): Administer once monthly, using twice the every 2 week dose; titrate as needed


Conversion From Epoetin alfa (EA):
EA dose under 8000 units/week: 60 mcg every 2 weeks OR 120 mcg monthly

EA dose 8000 to 16,000 units/week: 100 mcg every 2 weeks OR 200 mcg monthly

EA dose over 16,000 units/week: 180 mcg every 2 weeks OR 360 mcg monthly


Conversion From Darbepoetin alfa:
Darbepoetin alfa dose under 40 mcg/week: 60 mcg every 2 weeks OR 120 mcg monthly

Darbepoetin alfa dose 40 to 80 mcg /week: 100 mcg every 2 weeks OR 200 mcg monthly

Darbepoetin alfa dose over 80 mcg /week: 180 mcg every 2 weeks OR 360 mcg monthly


Comments:
-Use is neither indicated or recommended for anemia from cancer chemotherapy.
-Use is neither indicated or recommended as a substitute for red blood cell (RBC) transfusions when immediate correction of anemia is required.
-Improvements in symptoms, physical function, or health related quality of life have not been shown.
-Initiate therapy when hemoglobin is under 10 g/dL, the rate of hemoglobin decline is likely to require a RBC infusion, and reducing RBC transfusion related risks, including alloimmunization, is a goal.
-If hemoglobin exceeds 10 g/dL, reduce or interrupt dose.
-Use the lowest dose necessary to reduce the need for red blood cell transfusions.


Use: Anemia due to chronic kidney disease

Detailed Epoetin beta-methoxy polyethylene glycol dosage information
Epoetin beta and methoxy polyethylene glycol Dosage information (more detail)

Before Taking

You should not use this medicine if you are allergic to epoetin beta or methoxy polyethylene glycol, or if you have:

  • uncontrolled hypertension (high blood pressure); or

  • if you have ever had a type of anemia called pure red cell aplasia (PRCA).

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using epoetin beta and methoxy polyethylene glycol.

Tell your doctor if you have ever had:

  • heart disease, high blood pressure;

  • a seizure;

  • dialysis treatment; or

  • cancer.

Tell your doctor if you are pregnant or breastfeeding.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Epoetin beta and methoxy polyethylene glycol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Epoetin beta and methoxy polyethylene glycol side effects

Get emergency medical help if you have signs of an allergic reaction (hives, itching, sweating, wheezing, difficult breathing, dizziness, swelling in your face or throat, fainting) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

This medicine can increase your risk of serious or fatal side effects. Call your doctor or get emergency medical help if you have:

  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed;

  • symptoms of heart failure--shortness of breath (even with mild exertion), swelling, rapid weight gain;

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or

  • signs of a stroke or blood clot--sudden numbness or weakness (especially on one side of the body), slurred speech, sudden confusion, problems with vision or balance, a cold or pale arm or leg.

Also call your doctor at once if you have a seizure (convulsions), or signs that you may have a seizure, such as:

  • sudden mood changes;

  • unusual tiredness;

  • sensitivity to light or noise; or

  • trouble concentrating.

Common side effects of epoetin beta and methoxy polyethylene glycol may include:

  • diarrhea; or

  • stuffy nose, sinus pain; or

  • sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Epoetin beta and methoxy polyethylene glycol Side Effects

What other drugs will affect Epoetin beta and methoxy polyethylene glycol?

Other drugs may affect epoetin beta and methoxy polyethylene glycol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about Epoetin beta and methoxy polyethylene glycol (Epoetin beta and methoxy polyethylene glycol [ e-poe-e-tin-bay-ta-meth-ox-ee-pol-ee-eth-il-een-glye-kol ])

Dosage information
Epoetin beta and methoxy polyethylene glycol Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Recombinant human erythropoietins

Related treatment guides

Anemia Associated with Chronic Renal Failure
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