Eptinezumab-jjmr injection is used to help prevent migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Eptinezumab-jjmr injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes migraine headaches.

Eptinezumab-jjmr injection comes as a solution (liquid) to inject intravenously (into a vein) over 30 minutes by a doctor or nurse in a medical facility or infusion center. It is usually given every 3 months.

Your doctor may need to interrupt or stop your infusion if you experience certain side effects. Tell your doctor immediately if you experiences any of the following symptoms during your infusion: itching, rash, flushing, shortness of breath, wheezing, or face swelling.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Before receiving eptinezumab-jjmr injection,

• tell your doctor and pharmacist if you are allergic to eptinezumab-jjmr, any other medications, or any of the ingredients in eptinezumab-jjmr injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using eptinezumab-jjmr injection, call your doctor.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Unless your doctor tells you otherwise, continue your normal diet.

Eptinezumab-jjmr injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nasal congestion
• sore throat

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• swelling of your face, mouth, tongue, or throat
• difficulty breathing
• rash
• itching
• hives
• flushing of the face

Eptinezumab-jjmr injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor.

You should keep a headache diary by writing down when you have headaches. Be sure to share this information with your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.