Aflibercept ophthalmic (for the eyes) is used in adults to treat wet age-related macular degeneration, and macular edema following retinal vein occlusion.

Aflibercept ophthalmic is also used in adults to treat diabetic retinopathy, diabetic macular edema, and retinopathy of prematurity in premature babies.

Aflibercept ophthalmic may also be used for purposes not listed in this medication guide.

You should not use aflibercept if you are allergic to it, or if you have:

• swelling inside your eyes; or
• any type of infection (bacterial, fungal, viral) in or around your eyes.

Tell your doctor if you have ever had:

• inflammation of the eye or retina, retinal detachment;
• a blood clot or stroke; or
• glaucoma or another condition that increases pressure inside your eyes.

Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy before your first dose of this medicine. Keep using birth control during treatment and for at least 3 months after your last injection.

Do not breastfeed.

Use Eylea Hd (Intravitreal) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• eye pain or redness, swelling around your eyes;
• sudden vision problems;
• seeing flashes of light or "floaters" in your vision, seeing halos around lights;
• your eyes may be more sensitive to light;
• chest pain;
• sudden numbness or weakness, especially on one side of the body; or
• sudden severe headache, confusion, problems with speech or balance.

Common side effects may include:

• red or watery eyes;
• broken blood vessels in the eye;
• blurred vision;
• swelling of the eyelids; or
• mild eye pain or discomfort after the injection.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.