Famotidine is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces.

Famotidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome.

Famotidine also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

The Zantac 360 brand of this medicine does not contain ranitidine, a medicine that was withdrawn from market in the United States.

Before taking famotidine, tell your doctor if you have kidney or liver disease, a history of Long QT syndrome, stomach cancer or other problems, or asthma, COPD, or other breathing problems.

Famotidine may be only part of a complete program of treatment that also includes changes in diet or lifestyle habits. Follow your doctor's instructions very closely.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the jaw, arm or shoulder, nausea, sweating, anxiety, light-headedness and a general ill feeling.

Before taking this medicine

You should not use this medicine if you are allergic to famotidine or similar medicines such as ranitidine (Zantac), cimetidine (Tagamet), or nizatidine (Axid).

To make sure this medicine is safe for you, tell your doctor or pharmacist if you have ever had:

• kidney disease;

• liver disease;

• cancer stomach; or

• long QT syndrome (in you or a family member).

Ask a doctor before using famotidine if you are pregnant or breastfeeding.

Prescription famotidine comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once daily at bedtime or two to four times a day. Over-the-counter famotidine comes as a tablet, a chewable tablet, and a capsule to take by mouth. It is usually taken once or twice a day. To prevent symptoms, it is taken 15 to 60 minutes before eating foods or drinking drinks that may cause heartburn. Follow the directions on your prescription or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take famotidine exactly as directed. Do not take more or less of it or take it more often or for a longer time than prescribed by your doctor.

Shake the liquid well for 5 to 10 seconds before each use to mix the medicine evenly.

Swallow the tablets and capsules with a full glass of water.

Thoroughly chew the chewable tablets before swallowing them. Swallow the chewed tablet with a full glass of water.

Do not take more than two tablets, capsules, or chewable tablets of over-the-counter famotidine in 24 hours and do not take over-the-counter famotidine for longer than 2 weeks unless your doctor tells you that you should. If symptoms of heartburn, acid indigestion, or sour stomach last longer than 2 weeks, stop taking over-the-counter famotidine and call your doctor.

Use famotidine exactly as directed on the label, or as prescribed by your doctor.

Famotidine oral is taken by mouth.

Famotidine injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.

You may take famotidine oral with or without food.

Shake the bottle of Pepcid suspension (liquid) vigorously for 5 to 10 seconds prior to each use. Measure the liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Most ulcers heal within 4 weeks of treatment, but it may take up to 8 weeks of using this medicine before your ulcer heals. Keep using the medication as directed.

Call your doctor if the condition you are treating with this medicine does not improve, or if it gets worse while using this medicine.

Famotidine may be only part of a complete program of treatment that also includes changes in diet or lifestyle habits. Follow all instructions of your doctor or dietitian.

Store at room temperature away from moisture, heat, and light. Do not allow the liquid medicine to freeze.

Throw away any unused liquid that is older than 30 days.

You should not use this medicine if you are allergic to famotidine or similar medicines such as ranitidine (Zantac), cimetidine (Tagamet), or nizatidine (Axid).

To make sure this medicine is safe for you, tell your doctor or pharmacist if you have ever had:

• kidney disease;

• liver disease;

• cancer stomach; or

• long QT syndrome (in you or a family member).

Ask a doctor before using famotidine if you are pregnant or breastfeeding.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not allow the liquid to freeze. Dispose of unused famotidine liquid after 30 days.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unless your doctor tells you otherwise, continue your normal diet.

Avoid drinking alcohol. It can increase the risk of damage to your stomach.

Avoid taking other stomach acid reducers unless your doctor has told you to. However, you may take an antacid (such as Maalox, Mylanta, Gaviscon, Milk of Magnesia, Rolaids, or Tums) with famotidine.

Get emergency medical help if you have any signs of an allergic reaction to famotidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• confusion, hallucinations, agitation, lack of energy;

• a seizure;

• fast or pounding heartbeats, sudden dizziness (like you might pass out); or

• unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Some side effects may be more likely in older adults and in people who have severe kidney disease.

Common famotidine side effects may include:

• headache;

• dizziness; or

• constipation or diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Famotidine oral can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor if you are taking:

• cefditoren;

• dasatinib;

• delavirdine;

• fosamprenavir; or

• tizanidine (if you are taking famotidine liquid).

This list is not complete. Other drugs may interact with famotidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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