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Home > Drugs > Antimetabolites > Floxuridine
Antimetabolites

Floxuridine

https://themeditary.com/drug/floxuridine-7465.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 15, 2023  Additional Content by TheMediTary.Com

Generic name: floxuridine [ flox-ure-i-deen ]

Drug class: Antimetabolites

Dosage form: injectable powder for injection (0.5 g)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Floxuridine?

Floxuridine is used to treat digestive system cancers that have spread to the liver.

Floxuridine may also be used for purposes not listed in this medication guide.

Warnings

You should not use floxuridine if you have an infection, bone marrow suppression, or if you are malnourished.

How should I take Floxuridine

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Floxuridine is injected into an artery through an infusion pump. A healthcare provider will give you this injection.

You will be watched closely while receiving floxuridine, to make sure you do not have a severe reaction.

Floxuridine can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Dosing information

Usual Adult Dose for Liver Metastasis in Adenocarcinoma:

Recommended dose: 0.1 to 0.6 mg/kg/day by continuous arterial infusion; the higher dosage ranges (0.4 mg to 0.6 mg) are usually used for hepatic artery infusion because the liver metabolizes the drug (thus reducing the potential for systemic toxicity)

Comments:
-Therapy can be given until adverse reactions appear. When these side effects have subsided, therapy may be resumed.
-The patient should be maintained on therapy as long as response to floxuridine continues.

Use: For the palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Detailed Floxuridine dosage information
Floxuridine Dosage information (more detail)

Before Taking

You should not be treated with floxuridine if you have:

  • an infection;

  • bone marrow suppression; or

  • if you are malnourished.

Tell your doctor if you have ever had:

  • liver disease;

  • kidney disease;

  • radiation of your pelvic area; or

  • treatment with other chemotherapy medicines.

Floxuridine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using floxuridine.

What happens if I miss a dose?

Because you will receive floxuridine in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Floxuridine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using floxuridine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Floxuridine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Floxuridine may cause serious side effects. Call your doctor at once if you have:

  • chest pain or pressure;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

  • fever, chills, sore throat, mouth sores, feeling light-headed;

  • severe vomiting or diarrhea;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • easy bruising, unusual bleeding, purple or red spots under your skin; or

  • any bleeding that will not stop.

Common side effects of floxuridine may include:

  • nausea, vomiting, diarrhea, stomach cramps;

  • stomatitis;

  • abnormal blood tests; or

  • redness or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Floxuridine Side Effects

What other drugs will affect Floxuridine?

Other drugs may affect floxuridine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to floxuridine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Floxuridine (Floxuridine [ flox-ure-i-deen ])

Dosage information
Floxuridine Side Effects
During pregnancy
Drug images
Side effects
Drug class: Antimetabolites

Related treatment guides

Liver Metastasis in Adenocarcinoma
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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