Glofitamab is used to treat certain types of lymphoma in adults whose cancer has returned or did not respond to another treatment and who have received at least two previous cancer treatments.

Glofitamab may also be used for purposes not listed in this medication guide.

Tell your doctor if you have:

• an active or chronic infection; or
• kidney disease.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using glofitamab and for at least 1 month after your last dose. Tell your doctor right away if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Use Glofitamab (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers if you have signs of cytokine release syndrome (CRS), a serious side effect: fever, chills, trouble breathing, confusion, severe vomiting or diarrhea, fast or irregular heartbeats, feeling light-headed or very tired.

Call your doctor at once if you have:

• signs and symptoms of nervous system disorders--numbness, tingling or weakness of your hands or feet, sleepiness, dizziness, headache, memory problems, confusion, or disorientation, trouble speaking or understanding what is said to you, trouble concentrating, memory problems, tremors or shaking;
• signs or symptoms of tumor related problems--chest pain, cough, tender or swollen lymph nodes, pain or swelling at the site of the tumor; or
• signs of infection--fever, chills, sore throat, weakness, chest pain, cough, wheezing, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• abnormal lab results;
• muscle or bone pain;
• tiredness;
• rash;
• chills, shaking;
• fast or irregular heartbeat;
• dizziness, feeling light-headed; or
• fever with shortness of breath, trouble breathing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.