Glycopyrrolate helps to control conditions such as peptic ulcers that involve excessive stomach acid production.

Glycopyrrolate is also used to reduce drooling in children ages 3 to 16 who have certain medical conditions, such as cerebral palsy.

Glycopyrrolate injection is also used during surgery to reduce secretions in your stomach or airway, and to help protect your heart and nervous system while you are under general anesthesia.

Glycopyrrolate may also be used for purposes not listed in this medication guide.

You should not use glycopyrrolate if you have urination problems, a blockage in your stomach or intestines, severe constipation, severe ulcerative colitis or toxic megacolon, glaucoma, myasthenia gravis, or active bleeding with heart and blood circulation problems.

Glycopyrrolate comes as a tablet and solution (liquid) to take by mouth. For the treatment of ulcers, the tablet is usually taken 2 or 3 times a day. To reduce saliva and drooling in children with certain medical conditions, the solution is usually taken 3 times a day. Take the solution on an empty stomach (at least 1 hour before or 2 hours after a meal). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glycopyrrolate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start your child on a low dose of the solution and gradually increase the dose over a 4-week period.

If you are giving the solution to a child, do not use a household spoon to measure the dose. Use an oral syringe that is made especially for measuring liquid medication.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may need to take glycopyrrolate on an empty stomach, at least 1 hour before or 2 hours after a meal. Follow the instructions provided with your medicine.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Allow the orally disintegrating tablet to dissolve in your mouth without chewing. Swallow the tablet without water.

Glycopyrrolate doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Glycopyrrolate injection is given as an infusion into a vein or injected into a muscle. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.

You should not use glycopyrrolate if you are allergic to it, or if you have:

• a bladder obstruction or other urination problems;

• a stomach or bowel obstruction (including paralytic ileus);

• severe constipation;

• severe ulcerative colitis or toxic megacolon;

• glaucoma;

• myasthenia gravis; or

• active bleeding with fast heartbeats, low blood pressure, shortness of breath, and cold hands or feet.

Tell your doctor if you have ever had:

• an enlarged prostate;

• liver or kidney disease;

• heart problems or a heart rhythm disorder;

• high blood pressure;

• a stomach disorder such as ulcerative colitis, hiatal hernia, reflux disease, or slow digestion;

• a colostomy or ileostomy;

• a thyroid disorder; or

• a nerve disorder.

It is not known whether glycopyrrolate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using glycopyrrolate. Glycopyrrolate may slow breast milk production.

Do not give this medicine to a child without medical advice.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe muscle weakness, loss of movement, dilated pupils, jerky muscle movements, or seizure (convulsions).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unless your doctor tells you otherwise, continue your normal diet.

Avoid driving or hazardous activity until you know how glycopyrrolate will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol with this medicine can cause side effects.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Glycopyrrolate may cause serious side effects. Stop using glycopyrrolate and call your doctor at once if you have:

• severe constipation, severe stomach pain and bloating;

• diarrhea (especially if you have a colostomy or ileostomy);

• painful or difficult urination;

• fast or pounding heartbeats, fluttering in your chest;

• confusion, severe drowsiness;

• eye pain, seeing halos around lights;

• fever, shallow breathing, weak pulse, hot and red skin; or

• (in a child taking glycopyrrolate) dry diapers, fussiness, or excessive crying.

Common side effects of glycopyrrolate may include:

• constipation, nausea, vomiting, bloating;

• drowsiness, dizziness, weakness, feeling nervous;

• slow or fast heartbeats;

• sleep problems (insomnia);

• flushing (sudden warmth, redness, or tingly feeling);

• blurred vision, sensitivity to light;

• dry mouth, decreased sense of taste;

• decreased sweating, decreased urination;

• impotence, sexual problems;

• headache; or

• rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

• medicine to treat depression, anxiety, mood disorders, or mental illness;

• opioid medication;

• sleep medicine, cold or allergy medicine (Benadryl and others);

• medicine to treat Parkinson's disease;

• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

• medicine to treat overactive bladder;

• bronchodilator asthma medication; or

• seizure medication.

This list is not complete. Other drugs may affect glycopyrrolate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.