Glycopyrrolate and neostigmine is used in adults and children at least 2 years old to regain muscle function after surgery.

Glycopyrrolate and neostigmine may also be used for purposes not listed in this medication guide.

You should not use glycopyrrolate and neostigmine if you are allergic to it, or if you have:

• peritonitis (inflammation of the membrane lining the organs inside your abdomen);
• a stomach or bowel obstruction (including paralytic ileus);
• severe ulcerative colitis, toxic megacolon;
• a bladder obstruction or other urination problems;
• glaucoma;
• myasthenia gravis; or
• active bleeding with heart and blood circulation problems.

Tell your doctor if you have or have ever had:

• heart problems or a heart rhythm disorder;
• high blood pressure;
• a thyroid disorder;
• colostomy or ileostomy; or
• liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

Use Glycopyrrolate And Neostigmine (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe constipation, severe stomach pain and bloating;
• diarrhea (especially if you have a colostomy or ileostomy);
• painful or difficult urination;
• fast or pounding heartbeats, fluttering in your chest;
• confusion, severe drowsiness;
• fever, shallow breathing, weak pulse, hot and red skin; or
• eye pain, seeing halos around lights.

Common side effects may include:

• nausea, vomiting;
• dry mouth;
• difficult urination or urination problems;
• blurred vision, light sensitivity;
• decreased sweating; or
• slow or fast heartbeats, fluttering in your chest.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate and neostigmine can decrease sweating and you may be more prone to heat stroke.