Guaifenesin, hydrocodone, and pseudoephedrine is a combination medicine used to treat cough, stuffy nose, sinus congestion, and chest congestion caused by the common cold.

This medicine will not treat a cough with mucus, or cough that is caused by smoking, emphysema, or chronic bronchitis.

Guaifenesin, hydrocodone, and pseudoephedrine contains a narcotic cough medicine and may be habit-forming.

Guaifenesin, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to guaifenesin, hydrocodone, or pseudoephedrine, or if you have:

• narrow-angle glaucoma;
• severe or uncontrolled high blood pressure;
• coronary artery disease (clogged arteries); or
• if you are unable to urinate.

This medicine is not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had:

• asthma or other breathing problems;
• a head injury or increased pressure inside your skull;
• diabetes;
• thyroid disorder;
• Addison's disease (an adrenal gland disorder);
• liver or kidney disease;
• an enlarged prostate or urination problems; or
• stomach problems.

If you use hydrocodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not breast-feed. Hydrocodone can pass into breast milk and may cause drowsiness, breathing problems, or death in a nursing baby.

Use Guaifenesin, Hydrocodone, And Pseudoephedrine (Hycofenix) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

• noisy breathing, sighing, shallow breathing;
• confusion, severe weakness or drowsiness;
• tremors, severe restlessness;
• a seizure;
• irregular heartbeats;
• severe headache, blurred vision, pounding in your neck or ears;
• a light-headed feeling, like you might pass out;
• severe constipation, stomach pain; or
• adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Common side effects may include:

• dizziness, drowsiness;
• headache;
• sleep problems (insomnia);
• nausea; or
• low blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.