Hyaluronidase, pertuzumab, and trastuzumab is a combination cancer medicine that is used alone or with other medicines to treat early-stage breast cancer.

hyaluronidase, pertuzumab, and trastuzumab is also used to treat HER2-positive breast cancer that is advanced or has spread to other parts of the body (metastatic).

Hyaluronidase, pertuzumab, and trastuzumab is used for breast cancer only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Hyaluronidase, pertuzumab, and trastuzumab may also be used for purposes not listed in this medication guide.

hyaluronidase, pertuzumab, and trastuzumab can cause life-threatening heart or lung problems. Call your doctor at once if you have trouble breathing, swelling or rapid weight gain, fast or pounding heartbeats, or if you feel light-headed.

Do not use if you are pregnant. Use effective birth control during treatment and for at least 7 months after your last dose.

Hyaluronidase, pertuzumab, and trastuzumab is injected under the skin of your thigh. A healthcare provider will give you this injection.

hyaluronidase, pertuzumab, and trastuzumab is usually given once every 3 weeks for up to 1 year. Your doctor will determine how long to treat you with this medicine.

You will be watched closely for 15 to 30 minutes to make sure you do not have a serious reaction to this medicine.

Hyaluronidase, pertuzumab, and trastuzumab can have long lasting effects on your heart. Your heart function may need to be checked every 6 months for at least 2 years after your last dose.

For at least 7 months after your last dose of this medicine, make sure any doctor treating you with chemotherapy knows that you have received hyaluronidase, pertuzumab, and trastuzumab.

You should not be treated with this medicine if you are allergic to hyaluronidase, pertuzumab, or trastuzumab.

Tell your doctor if you have ever had:

• congestive heart failure;

• a heart attack or heart rhythm disorder;

• uncontrolled high blood pressure;

• a weak immune system caused by chemotherapy; or

• chemotherapy treatment with doxorubicin.

You may need to have a negative pregnancy test before starting this treatment.

Do not use hyaluronidase, pertuzumab, and trastuzumab if you are pregnant. It could cause birth defects or death to the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose. Tell your doctor right away if you think you might be pregnant.

If you are pregnant or you become pregnant within 7 months after being treated with this medicine: Your name may be listed on a pregnancy registry to track the effects of hyaluronidase, pertuzumab, and trastuzumab on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Call your doctor for instructions if you miss an appointment for your hyaluronidase, pertuzumab, and trastuzumab injection.

Since hyaluronidase, pertuzumab, and trastuzumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction: hives, rash; fever, chills, dizziness; nausea, vomiting, diarrhea; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine can cause life-threatening heart or lung problems. Call your doctor at once if you have:

• a new or worsening cough or shortness of breath (even while at rest);

• fast or pounding heartbeats;

• severe headache, blurred vision, pounding in your neck or ears;

• swelling in your face or lower legs;

• rapid weight gain (more than 5 pounds in 24 hours);

• a light-headed feeling, like you might pass out;

• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or

• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of hyaluronidase, pertuzumab, and trastuzumab may include:

• nausea, diarrhea;

• anemia;

• feeling weak or tired;

• hair loss;

• rash; or

• numbness, tingling, or burning pain in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may affect hyaluronidase, pertuzumab, and trastuzumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.