Imipenem, cilastatin, and relebactam is a combination medicine that is used to treat complicated infections of the urinary tract (bladder and kidneys) or infections within the stomach area (abdomen).

Imipenem, cilastatin, and relebactam is also used to treat pneumonia (a lung infection) caused by being in a hospital or using a ventilator.

This medicine is for use in adults who have few or no other treatment options.

Imipenem, cilastatin, and relebactam may also be used for purposes not listed in this medication guide.

You should not be treated with this medicine if you are allergic to imipenem, cilastatin, or relebactam.

Tell your doctor if you have ever had:

• a seizure;
• a stroke; or
• an allergic reaction to penicillin or other antibiotic medicines.

Tell your doctor if you are pregnant or breastfeeding.

Use Imipenem, Cilastatin, And Relebactam (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• tremors;
• a seizure; or
• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects may include:

• increased blood pressure;
• nausea, diarrhea, vomiting;
• abnormal liver function tests;
• fever;
• headache; or
• pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.