Iopamidol is a radiopaque (RAY dee oh payk) contrast agent. Iopamidol contains iodine, a substance that absorbs x-rays. Radiopaque contrast agents are used to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on a CT scan or other radiologic (x-ray) examination.

Iopamidol is used to help diagnose certain disorders of the heart, brain, blood vessels, and nervous system.

Iopamidol may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• any type of reaction to another contrast agent;
• liver or kidney disease;
• heart disease, including congestive heart failure;
• a stroke, blood clots, or coronary artery disease;
• asthma, hay fever, food allergies;
• epilepsy or other seizure disorder;
• sickle cell anemia;
• diabetes;
• an active infection;
• pheochromocytoma (tumor of the adrenal gland);
• multiple myeloma (bone cancer); or
• a thyroid disorder.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Tell your doctor if you are breast-feeding.

Use Iopamidol-370 (Injectable) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

• a light-headed feeling, like you might pass out;
• swelling, rapid weight gain, little or no urinating;
• wheezing or trouble breathing;
• seizure (convulsions);
• swelling in your neck or throat (enlarged thyroid);
• thyroid symptoms--extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain;
• heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, coughing up blood; or
• signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects may include:

• chest pain;
• slow heart rate;
• hot flashes, burning sensation;
• flushing (warmth, redness, or tingly feeling);
• nausea;
• hives; or
• dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not allow yourself to become dehydrated during the first few days after receiving iopamidol. Call your doctor if you have any vomiting or diarrhea during this time. Follow your doctor's instructions about the types and amount of fluids you should drink.