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Home > Drugs > Ipratropium (eent) (monograph)
Drugs

Ipratropium (eent) (monograph)

https://themeditary.com/drug/ipratropium-eent-monograph-5068.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 11, 2023  Additional Content by TheMediTary.Com

Generic name: medically reviewed

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Atrovent nasal, Ipratropium nasal

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Ipratropium (eent) (monograph)?

Introduction

Synthetic quaternary ammonium antimuscarinic.

Uses for Ipratropium (EENT)

Common Cold

Symptomatic relief of rhinorrhea associated with the common cold in adults and children ≥5 years of age. Does not relieve nasal congestion or sneezing.

Seasonal Allergic Rhinitis

Symptomatic relief of rhinorrhea associated with seasonal allergic rhinitis in adults and children ≥5 years of age. Does not relieve nasal congestion, sneezing, or itching eyes.

Perennial Rhinitis

Symptomatic relief of rhinorrhea associated with allergic and nonallergic perennial rhinitis in adults and children ≥6 years of age. Does not relieve nasal congestion, sneezing, or postnasal drip.

Ipratropium (EENT) Dosage and Administration

Administration

Intranasal Administration

Administer in each nostril 2–4 times daily using spray pump supplied by the manufacturer.

Prime pump before first dose with 7 sprays; if used regularly, no further priming required. If not used for >24 hours, reprime with 2 sprays; if not used for >7 days, reprime with 7 sprays.

Dosage

Intranasal spray pump delivers 0.07 mL of solution per actuation.

Ipratropium bromide 0.03% nasal spray delivers 21 mcg of ipratropium bromide per spray and about 345 sprays per bottle.

Ipratropium bromide 0.06% nasal spray delivers 42 mcg of ipratropium bromide per spray and about 165 sprays per bottle.

Pediatric Patients

Common Cold
Intranasal

Children 5–11 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 3 times daily.

Children ≥12 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 3 or 4 times daily.

Seasonal Allergic Rhinitis
Intranasal

Children ≥5 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 4 times daily.

Perennial Rhinitis
Intranasal

Children ≥6 years of age: 42 mcg (2 sprays of the 0.03% solution) in each nostril 2 or 3 times daily.

Adults

Common Cold
Intranasal

84 mcg (2 sprays of the 0.06% solution) in each nostril 3 or 4 times daily.

Seasonal Allergic Rhinitis
Intranasal

84 mcg (2 sprays of the 0.06% solution) in each nostril 4 times daily.

Perennial Rhinitis
Intranasal

42 mcg (2 sprays of the 0.03% solution) in each nostril 2 or 3 times daily.

Prescribing Limits

Pediatric Patients

Common Cold
Intranasal

Safety and efficacy beyond 4 days not established.

Seasonal Allergic Rhinitis
Intranasal

Safety and efficacy beyond 3 weeks not established.

Adults

Common Cold
Intranasal

Safety and efficacy beyond 4 days not established.

Seasonal Allergic Rhinitis
Intranasal

Safety and efficacy beyond 3 weeks not established.

Detailed Ipratropium nasal dosage information

Warnings

Contraindications

  • Known hypersensitivity to ipratropium or any ingredient in the formulation, or to atropine or its derivatives.

Warnings/Precautions

Sensitivity Reactions

Hypersensitivity Reactions

Immediate hypersensitivity reactions, including urticaria, angioedema, rash, bronchospasm, and oropharyngeal edema, may occur.

General Precautions

Ocular Effects

Caution in patients with angle-closure glaucoma. Ocular pain or precipitation or worsening of angle-closure glaucoma reported following inadvertent contact of the drug with the eyes.

Genitourinary Effects

Caution in patients with prostatic hypertrophy or bladder neck obstruction.

Specific Populations

Pregnancy

Category B.

Lactation

Not known whether ipratropium is distributed into milk following intranasal administration. Caution advised.

Pediatric Use

Safety established based on studies in children.

Efficacy based on extrapolation from studies in adults with perennial rhinitis and adults and adolescents with common cold or seasonal allergic rhinitis and on the likelihood that the disease course, pathophysiology, and the drug’s effect in children are similar to those in adults.

Safety and efficacy of 0.03% nasal spray not established in children <6 years of age.

Safety and efficacy of 0.06% nasal spray not established in children <5 years of age.

Common Adverse Effects

Nasal dryness, epistaxis.

How should I use Ipratropium (eent) (monograph)

Administration

Intranasal Administration

Administer in each nostril 2–4 times daily using spray pump supplied by the manufacturer.

Prime pump before first dose with 7 sprays; if used regularly, no further priming required. If not used for >24 hours, reprime with 2 sprays; if not used for >7 days, reprime with 7 sprays.

Dosage

Intranasal spray pump delivers 0.07 mL of solution per actuation.

Ipratropium bromide 0.03% nasal spray delivers 21 mcg of ipratropium bromide per spray and about 345 sprays per bottle.

Ipratropium bromide 0.06% nasal spray delivers 42 mcg of ipratropium bromide per spray and about 165 sprays per bottle.

Pediatric Patients

Common Cold
Intranasal

Children 5–11 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 3 times daily.

Children ≥12 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 3 or 4 times daily.

Seasonal Allergic Rhinitis
Intranasal

Children ≥5 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 4 times daily.

Perennial Rhinitis
Intranasal

Children ≥6 years of age: 42 mcg (2 sprays of the 0.03% solution) in each nostril 2 or 3 times daily.

Adults

Common Cold
Intranasal

84 mcg (2 sprays of the 0.06% solution) in each nostril 3 or 4 times daily.

Seasonal Allergic Rhinitis
Intranasal

84 mcg (2 sprays of the 0.06% solution) in each nostril 4 times daily.

Perennial Rhinitis
Intranasal

42 mcg (2 sprays of the 0.03% solution) in each nostril 2 or 3 times daily.

Prescribing Limits

Pediatric Patients

Common Cold
Intranasal

Safety and efficacy beyond 4 days not established.

Seasonal Allergic Rhinitis
Intranasal

Safety and efficacy beyond 3 weeks not established.

Adults

Common Cold
Intranasal

Safety and efficacy beyond 4 days not established.

Seasonal Allergic Rhinitis
Intranasal

Safety and efficacy beyond 3 weeks not established.

Detailed Ipratropium nasal dosage information
Ipratropium (eent) (monograph) Dosage information (more detail)

What other drugs will affect Ipratropium (eent) (monograph)?

Limited systemic absorption of intranasal ipratropium minimizes potential for interactions with systemically administered drugs.

Antimuscarinic Agents

Potential for additive pharmacologic effect with other antimuscarinic agents, including orally inhaled ipratropium.

More about Ipratropium (eent) (monograph) (Medically reviewed)

Dosage information
Ipratropium (eent) (monograph) Side Effects
During pregnancy
Ipratropium Nasal 0.03 Prescribing Information
Drug images
Side effects
Drug class: Drugs

Related treatment guides

Rhinorrhea
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