Irinotecan liposomal is used to treat pancreatic cancer that has spread to other parts of the body (metastatic). Irinotecan liposomal is usually given in combination with other cancer medicines.

Irinotecan liposomal may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to irinotecan.

Tell your doctor if you have ever had:

• liver or kidney disease;
• lung disease; or
• an intestinal disorder or obstruction.

Irinotecan liposomal can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you may need to have a negative pregnancy test. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.
• If you are a man, use condoms if your sex partner is able to get pregnant. Keep using condoms for at least 4 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using irinotecan liposomal.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Use Irinotecan Liposomal (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe or ongoing vomiting or diarrhea;
• black or bloody stools;
• sores or white patches in or around your mouth;
• new or worsening cough or shortness of breath;
• dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
• low blood cell counts--fever, tiredness, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed; or
• symptoms of sepsis--confusion, fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.

Common side effects may include:

• fever, mouth sores, or other signs of infection;
• diarrhea;
• nausea, vomiting, loss of appetite; or
• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.