Omeprazole and sodium bicarbonate is a combination medicine used in adults to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD).

Omeprazole and sodium bicarbonate can also be used to reduce the risk of stomach bleeding in patients who are in the intensive care unit (ICU).

This medicine may also be used to treat certain types of ulcers and promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Omeprazole and sodium bicarbonate may also be used for purposes not listed in this medication guide.

You should not use omeprazole and sodium bicarbonate if you are allergic to it, or if you have:

• an allergy to any other stomach acid medicine such as lansoprazole, rabeprazole, esomeprazole, pantoprazole, and others.

Some drugs should not be used with omeprazole and sodium bicarbonate. Your treatment plan may change if you also use any medication that contains rilpivirine.

Tell your doctor if you have or have ever had:

• any allergies or medical conditions;
• congestive heart failure;
• problems with acid-base (pH) balance in your body;
• an electrolyte imbalance (such as low blood levels of calcium, potassium, or magnesium);
• taken medicine to prevent organ transplant rejection;
• if you are on a low-salt diet;
• liver disease; or
• a kidney disorder called Bartter's syndrome.

You may be more likely to have a broken bone while using omeprazole and sodium bicarbonate. Talk with your doctor about ways to keep your bones healthy.

Tell your doctor if you are pregnant or breastfeeding.

Use Konvomep (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Long-term use of omeprazole and sodium bicarbonate may increase your risk of serious side effects including stomach polyps. Talk with your doctor about these risks.

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody;
• sudden pain or trouble moving your hip, wrist, or back;
• confusion, dizziness or lightheadedness;
• a seizure;
• low blood magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling;
• kidney problems--pain in your side or lower back, painful urination, blood or pus in your urine;
• new or worsening symptoms of lupus--joint pain and a skin rash on your cheeks or arms that worsens in sunlight; or
• vitamin B12 deficiency--shortness of breath, feeling lightheaded, irregular heartbeats, muscle weakness, pale skin, tiredness, mood changes.

Common side effects may include:

• headache;
• nausea, vomiting, stomach pain, gas; or
• diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not change the amount of salt in your diet unless your doctor tells you to.

Ask a doctor or pharmacist before using over-the-counter medicines that may contain ingredients similar to this medicine.

Ask your doctor about calcium sources in your diet. Getting too much calcium while taking omeprazole and sodium bicarbonate may cause harmful side effects.