Lamotrigine is an anti-epileptic medication, also called an anticonvulsant.

Lamotrigine is used alone or with other medications to treat epileptic seizures in adults and children. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder (manic depression).

Immediate-release lamotrigine can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old.

Extended-release lamotrigine is for use only in adults and children who are at least 13 years old.

Lamotrigine may also be used for purposes not listed in this medication guide.

You should not take lamotrigine if you are allergic to it.

Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote).

Tell your doctor if you have ever had:

• a rash or allergic reaction after taking another seizure medication;
• kidney or liver disease;
• heart problems such as heart block or irregular heartbeats;
• depression, suicidal thoughts or actions; or
• meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking lamotrigine.

Some people have thoughts about suicide while taking lamotrigine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lamotrigine on the baby.

Birth control pills can make lamotrigine less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your lamotrigine dose may need to be changed.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Use Lamictal ODT Patient Titration Kit (Orange)(Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• fast, slow, or pounding heartbeats or fluttering in your chest;
• chest pain, shortness of breath;
• fever, swollen glands, weakness, severe muscle pain;
• any skin rash, especially with blistering or peeling;
• painful sores in your mouth or around your eyes;
• headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness;
• jaundice (yellowing of the skin or eyes); or
• pale skin, cold hands and feet, easy bruising, unusual bleeding.

Common side effects may include:

• headache, dizziness;
• blurred vision, double vision;
• tremor, loss of coordination;
• dry mouth, nausea, vomiting, stomach pain, diarrhea;
• fever, sore throat, runny nose;
• drowsiness, tired feeling;
• back pain; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.