Contraindications
Warnings/Precautions
General Precautions
GI Disease
Safety and efficacy not established in active peptic ulcer disease, ulcerative colitis, Crohn’s disease, or bowel obstruction; use with caution in patients with these disorders.
Radiographic Examinations
Abdominal radiographs performed in patients taking lanthanum may have the typical radiopaque appearance of a radiograph performed using an imaging agent.
Chronic Use
No differences in fracture or mortality rates were observed between patients receiving lanthanum and those receiving alternative therapy for up to 3 years in clinical studies; however, data are insufficient to conclude lanthanum has no effect on fracture or mortality rates beyond 3 years of use.
Specific Populations
Pregnancy
Category C.
Lactation
Not known whether lanthanum is distributed into milk. Caution if used in nursing women.
Pediatric Use
Safety and efficacy not established in children <18 years of age.
Deposited in developing bone (including the growth plate) of animals in long-term studies; although growth abnormalities in animals were not observed, the consequences of deposition in developing bone of pediatric patients are unknown.
Geriatric Use
No substantial differences in safety and efficacy relative to younger adults.
Common Adverse Effects
Nausea, vomiting, dialysis graft occlusion, abdominal pain.
