Generic name: Cladribine (injection)
Pregnancy & Lactation: Risk data not available
What is Leustatin?
Cladribine is a cancer medicine that is used to treat hairy cell leukemia (a type of blood cancer).
Cladribine may also be used for purposes not listed in this medication guide.
Warnings
You should not use cladribine if you are allergic to it.
Tell your doctor if you have ever had:
- heart problems;
- liver or kidney disease; or
- weak immune system (caused by disease or by using certain medicine).
Cladribine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
You should not breastfeed while using cladribine.
How should I use Leustatin
Use Leustatin (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Cladribine is given as an infusion into a vein. A healthcare provider will give you this injection.
Cladribine is usually given around the clock for 7 days in a row. Your doctor will determine how many 7- day treatments you will receive and how often.
Cladribine can increase your risk of bleeding or infection. You will need frequent medical tests, and your next dose may be delayed based on the results.
If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.
Since this medication is given in a healthcare setting around the clock, you will not miss a dose.
Leustatin side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- numbness, tingling, weakness, or burning pain in your fingers or toes;
- loss of movement in any part of your body;
- redness, swelling, or itching under your skin;
- low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
- signs of infection--fever, chills, cough, chest pain, mouth sores, skin sores, sore throat, trouble breathing; or
- signs of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.
Common side effects may include:
- fever;
- nausea, vomiting, diarrhea;
- headache, tiredness;
- rash;
- cough; or
- pain, bruising, swelling, or irritation where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Leustatin?
Do not receive a "live" vaccine while using cladribine, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.