Lopinavir and ritonavir is a combination antiviral medicine used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Lopinavir and ritonavir is for use in adults and children who are at least 14 days old.

Lopinavir and ritonavir may also be used for purposes not listed in this medication guide.

You should not use this medicine if you have ever had a severe allergic reaction to lopinavir or ritonavir.

Some medicines can cause unwanted or dangerous effects when used with lopinavir and ritonavir. Your doctor may change your treatment plan if you also use:

• apalutamide;
• alfuzosin;
• cisapride;
• colchicine;
• dronedarone;
• elbasvir/grazoprevir;
• lomitapide;
• lurasidone, pimozide;
• ranolazine;
• rifampin;
• lovastatin, simvastatin;
• triazolam, or oral midazolam;
• sildenafil (Revatio for pulmonary arterial hypertension);
• St. John's wort; or
• an ergot medicine (ergotamine, dihydroergotamine, methylergonovine).

Tell your doctor if you have ever had:

• liver disease (especially hepatitis B or C);
• heart problems;
• long QT syndrome (in you or a family member);
• pancreas problems;
• diabetes;
• high cholesterol;
• low levels of potassium in your blood; or
• a bleeding disorder such as hemophilia.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Lopinavir and ritonavir oral solution (liquid) contains alcohol and propylene glycol. Do not use the liquid form of this medicine if you become pregnant.

Lopinavir and ritonavir can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using lopinavir and ritonavir, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.

Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Use Lopinavir And Ritonavir (Kaletra) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
• signs of a kidney stone--pain in your side or lower back, blood in your urine, painful or difficult urination;
• high blood sugar--increased thirst, increased urination, fruity breath odor, weight loss; or
• signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Lopinavir and ritonavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

• signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
• trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
• swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Lopinavir and ritonavir liquid contains alcohol and propylene glycol, which may cause drowsiness or slow breathing in a baby taking this medicine. Tell your doctor if you notice these symptoms in your baby.

Lopinavir and ritonavir can cause changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Common side effects may include:

• nausea, vomiting, diarrhea; or
• high cholesterol or triglycerides.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lopinavir and ritonavir liquid contains alcohol and propylene glycol. Avoid drinking alcohol while using this medicine.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.