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Home > Drugs > Atypical antipsychotics > Lumateperone
Atypical antipsychotics

Lumateperone

https://themeditary.com/drug/lumateperone-6310.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 13, 2023  Additional Content by TheMediTary.Com

Generic name: lumateperone [ loo-ma-te-per-one ]

Drug class: Atypical antipsychotics

Dosage form: oral capsule (10.5 mg; 21 mg; 42 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Caplyta

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Lumateperone?

Lumateperone is used in adults to treat schizophrenia.

Lumateperone is also used alone or with lithium or valproate to treat depression with bipolar disorder (manic depression).

Lumateperone may also be used for purposes not listed in this medication guide.

Warnings

Lumateperone is not approved for use in older adults with dementia-related psychosis.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

How should I take Lumateperone

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take once a day with or with food.

Your treatment may also include weight control, and frequent medical tests.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Schizophrenia:

42 mg orally once a day

Use: For the treatment of schizophrenia

Usual Adult Dose for Bipolar Disorder:

42 mg orally once a day

Use: As monotherapy or as adjunctive therapy with lithium or valproate, for the treatment of depressive episodes associated with bipolar I or II disorder (bipolar depression)

Detailed Lumateperone dosage information
Lumateperone Dosage information (more detail)

Before Taking

You should not use lumateperone if you are allergic to it.

Lumateperone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have or have ever had:

  • heart problems or a stroke;

  • high or low blood pressure;

  • seizures;

  • trouble swallowing;

  • low white blood cell count;

  • high cholesterol or triglycerides;

  • diabetes or high blood sugar, or a family history of diabetes or high blood sugar; or

  • liver or kidney disease.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.

You should not breastfeed while using lumateperone.

lumateperone may affect fertility (your ability to have children), whether you are a man or a woman.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not drink grapefruit juice or eat grapefruit while taking this medication.

What should I avoid while using Lumateperone?

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid driving or hazardous activity until you know how lumateperone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Lumateperone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Lumateperone may cause serious side effects. Call your doctor at once if you have:

  • feeling unsteady, feeling like you might pass out;

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • tightness in your neck or throat, trouble swallowing;

  • trouble breathing or speaking;

  • a seizure;

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

  • low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects of lumateperone may include:

  • nausea;

  • dizziness;

  • drowsiness; or

  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Lumateperone Side Effects

What other drugs will affect Lumateperone?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect lumateperone, especially:

  • an antibiotic, antifungal, or antiviral medicine;

  • blood pressure medication;

  • bronchodilator asthma medication;

  • cold or allergy medicine (Benadryl and others);

  • medicine to treat depression, anxiety, mood disorders, or mental illness;

  • medicine to treat overactive bladder;

  • medicine to treat Parkinson's disease;

  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

  • seizure medicine; or

  • St. John's wort.

This list is not complete and many other drugs may affect lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Lumateperone (Lumateperone [ loo-ma-te-per-one ])

Dosage information
Lumateperone Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Atypical antipsychotics

Related treatment guides

Bipolar Disorder
Schizophrenia
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