Generic name: magnesium, potassium, and sodium sulfates [ mag-nee-see-um-sul-fate, poe-ta-see-um-sul-fate, and-soe-dee-um-sul-fate ]
Drug class: Laxatives
Dosage form: oral liquid (1.6 g-3.13 g-17.5 g/177 ml)
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Suprep bowel prep, Suprep bowel prep kit
What is Magnesium sulfate, potassium sulfate, and sodium sulfate?
Magnesium, potassium, and sodium are electrolyte minerals that occur naturally in body fluids.
Magnesium, potassium, and sodium sulfates bowel prep kit is a combination medicine that causes diarrhea for the purpose of cleaning your colon before a colonoscopy. Cleaning the colon allows the inside of your colon to be seen more clearly on the colonoscopy.
This medicine is for use in adults and children at least 12 years old.
Magnesium, potassium, and sodium sulfates may also be used for purposes not listed in this medication guide.
Warnings
This medicine can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, or kidney failure.
Call your doctor if you are sick with vomiting and cannot drink enough water for your bowel prep, or if you have a headache, dizziness, or decreased urination.
How should I take Magnesium sulfate, potassium sulfate, and sodium sulfate
Magnesium sulfate, potassium sulfate, and sodium sulfate comes as a comes as a solution (liquid) (Suprep®) and as tablets (Sutab®) to take by mouth. The first dose is usually taken the night before the colonoscopy and the second dose taken the morning of the procedure. Your doctor will tell you exactly when you should take your medication. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take magnesium sulfate, potassium sulfate, and sodium sulfate exactly as directed. Do not take more or less of it than prescribed by your doctor.
To prepare for your colonoscopy, you may not eat any solid food or drink milk beginning the day before the procedure. You should only have clear liquids during this time. Examples of clear liquids are water, light colored fruit juice without pulp, clear broth, coffee or tea without milk, flavored gelatin, popsicles, and soft drinks. Do not drink alcoholic beverages or any liquid that is red or purple. Ask your doctor if you have any questions about which liquids you may drink before your colonoscopy. Tell your doctor if you have trouble drinking clear liquids.
If you are taking the solution (Suprep®), you will need to mix the medication solution with water right before you take it. If you swallow the solution without mixing it with water, there is a greater chance that you will experience unpleasant or dangerous side effects. To prepare each dose of your medication, pour the contents of one bottle of magnesium sulfate, potassium sulfate, and sodium sulfate solution into the dosing container that was provided with the medication and fill the container with water up to the line (16 ounces, 480 mL or 12 ounces, 300 mL) that is marked on the cup. Drink the entire mixture right away. You will take your first dose on the evening before your colonoscopy. After you take this dose, you will need to drink two containers (16 ounces, 480 mL or 12 ounces, 300 mL) of water within the next hour before you go to bed. You will take your second dose the next morning before your colonoscopy is scheduled. After you take the second dose, you will need to drink two containers (16 ounces, 480 mL or 12 ounces, 300 mL) of water within the next hour, but you should finish all the drinks at least 2 hours before your colonoscopy.
If you are taking the tablets (Sutab®), each dose is 12 tablets. You will take your first dose (12 tablets) the evening before your colonoscopy is scheduled and your second dose (12 tablets) the following morning before your colonoscopy is scheduled. For each dose, you will need to fill the container that was provided with water up to the line (16 ounces, 480 mL) that is marked on the cup. You should take each tablet with a sip of water and then drink the entire contents of the cup over 15 to 20 minutes. Approximately 1 hour after you take a dose (12 tablets), you will need to drink one 16-ounce container of water over 30 minutes; 30 minutes after finishing the second container of water, you will need to drink another 16-ounce container of water over 30 minutes. After you take the second dose (12 tablets), you should finish all the drinks at least 2 hours before your colonoscopy.
You will have many bowel movements during your treatment with magnesium sulfate, potassium sulfate, and sodium sulfate. Be sure to stay close to a toilet from the time you take your first dose of the medication until the time of your colonoscopy appointment. Ask your doctor about other things you can do to stay comfortable during this time.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with this medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Dosing information
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Never use an adult-strength bowel prep kit in anyone 12 to 18 years old.
Carefully follow all instructions about what to eat or drink in the days before your colon prep.
You must dilute this medicine with water before drinking it. Drinking the pure liquid can increase your risk of nausea, vomiting, or dehydration.
Do not eat solid food once you start taking this medicine.
You will need to drink extra water once you start your colon prep. Drink only clear liquids and avoid alcohol, milk, or any drink that is red or purple.
This medicine can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, or kidney failure. Call your doctor if you are sick with vomiting and cannot drink enough water for your bowel prep, or if you have a headache, dizziness, or decreased urination.
Store at room temperature.
Before Taking
You should not use this medicine if you are allergic to magnesium sulfate, potassium sulfate, or sodium sulfate, or if you have:
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a bowel obstruction, colitis or toxic megacolon;
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a dilated intestine;
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a perforation (a hole or tear) of your intestines; or
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slow digestion.
Tell your doctor if you have ever had:
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heart problems, including long QT syndrome;
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a stomach or intestinal disorder;
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ulcerative colitis;
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an electrolyte imbalance (such as low levels of potassium, magnesium, or sodium in your blood);
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gastroesophageal reflux disease (GERD);
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a sensitive gag reflex, or trouble swallowing;
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a seizure;
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kidney disease;
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gout; or
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alcohol or opioid withdrawal.
Tell your doctor if you are pregnant or breastfeeding.
Magnesium, potassium, and sodium sulfates is not approved for use by anyone younger than 12 years old.
What happens if I miss a dose?
Call your doctor if you cannot drink the entire amount of medicine and liquids as instructed in time for your colonoscopy.
What happens if I overdose?
An overdose is unlikely to occur if you take magnesium sulfate, potassium sulfate, and sodium sulfate exactly as directed.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What special dietary instructions should I follow?
Your doctor will tell you what you may eat and drink before, during, and after your treatment with magnesium sulfate, potassium sulfate, and sodium sulfate. Follow these directions carefully.
What should I avoid while using Magnesium sulfate, potassium sulfate, and sodium sulfate?
Do not take other laxatives during your colon prep.
Magnesium sulfate, potassium sulfate, and sodium sulfate side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor right away if you have:
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a headache and dizziness;
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little or no urination;
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severe nausea or vomiting;
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painful bloating or stomach cramps;
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trouble drinking liquids;
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mouth sores;
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a seizure;
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irregular heartbeats; or
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worsening gout symptoms (joint pain, redness, or swelling).
Common side effects of magnesium sulfate, potassium sulfate, and sodium sulfate may include:
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stomach pain or discomfort;
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nausea, vomiting; or
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mild bloating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See more: Magnesium sulfate, potassium sulfate, and sodium sulfate Side EffectsWhat other drugs will affect Magnesium sulfate, potassium sulfate, and sodium sulfate?
Magnesium, potassium, and sodium sulfates can make it harder for your body to absorb other medicines you take by mouth within 1 hour before your colon prep.
Tell your doctor about all your other medicines, especially:
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a laxative;
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heart or blood pressure medication;
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a diuretic or "water pill";
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medicine to treat a kidney problem;
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seizure medication; or
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NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect magnesium, potassium, and sodium sulfates, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to magnesium sulfate, potassium sulfate, and sodium sulfate.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.