Medrol Dosepak is a steroid that prevents the release of substances in the body that cause inflammation.

Medrol Dosepak is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Medrol Dosepak may also be used for purposes not listed in this medication guide.

You should not use this medicine if you have a fungal infection anywhere in your body.

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Medrol Dosepak is sometimes taken every other day. Follow your doctor's dosing instructions very carefully.

Your dose needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Medrol Dosepak.

You should not stop using Medrol Dosepak suddenly. Follow your doctor's instructions about tapering your dose.

Wear a medical alert tag or carry an ID card stating that you take Medrol Dosepak. Any medical care provider who treats you should know that you take steroid medication.

If you need surgery, tell the surgeon ahead of time that you are using Medrol Dosepak. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

You should not use Medrol Dosepak if you are allergic to it, or if you have:

• a fungal infection anywhere in your body.

Medrol Dosepak can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

To make sure Medrol Dosepak is safe for you, tell your doctor if you have ever had:

• a thyroid disorder;

• herpes infection of the eyes;

• stomach ulcers, ulcerative colitis, or diverticulitis;

• depression, mental illness, or psychosis;

• liver disease (especially cirrhosis);

• high blood pressure;

• osteoporosis;

• a muscle disorder such as myasthenia gravis; or

• multiple sclerosis.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

It is not known whether Medrol Dosepak will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether methylprednisolone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Call your doctor for instructions if you miss a dose of Medrol Dosepak.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of methylprednisolone is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while using Medrol Dosepak. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Medrol Dosepak may cause serious side effects. Call your doctor at once if you have:

• shortness of breath (even with mild exertion), swelling, rapid weight gain;

• bruising, thinning skin, or any wound that will not heal;

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;

• severe depression, changes in personality, unusual thoughts or behavior;

• new or unusual pain in an arm or leg or in your back;

• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

• seizure (convulsions); or

• low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Medrol Dosepak.

Common side effects of Medrol Dosepak may include:

• fluid retention (swelling in your hands or ankles);

• dizziness, spinning sensation;

• changes in your menstrual periods;

• headache;

• mild muscle pain or weakness; or

• stomach discomfort, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may interact with methylprednisolone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.