Melphalan flufenamide is used together with dexamethasone (a steroid medicine) to treat adults with multiple myeloma.

Melphalan flufenamide is given after at least four other cancer treatments did not work or have stopped working.

Melphalan flufenamide may also be used for purposes not listed in this medication guide.

You should not be treated with melphalan flufenamide if you are allergic to it.

Tell your doctor if you have any type of infection.

Using melphalan flufenamide may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Melphalan flufenamide can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, do not use melphalan flufenamide if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using melphalan flufenamide.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Use Melphalan Flufenamide (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• a new or worsening cough;
• pain or burning when you urinate; or
• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

• low blood cell counts;
• nausea, diarrhea;
• tiredness; or
• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.