Methylprednisolone is a steroid that prevents the release of substances in the body that cause inflammation.

Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Methylprednisolone may also be used for purposes not listed in this medication guide.

You should not be treated with methylprednisolone if you are allergic to it. You may not be able to receive a methylprednisolone injection if you have a fungal infection.

Methylprednisolone can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Tell your doctor if you have ever had:

• heart disease, high blood pressure;
• a thyroid disorder;
• diabetes;
• glaucoma or cataracts;
• kidney disease;
• cirrhosis or other liver disease;
• seizures, epilepsy or recent head injury;
• past or present tuberculosis;
• herpes infection of the eyes;
• a condition called scleroderma;
• stomach ulcers, ulcerative colitis, diverticulitis, or recent intestinal surgery;
• a parasite infection that causes diarrhea (such as threadworms);
• mental illness or psychosis;
• osteoporosis or low bone mineral density (steroid medication can increase your risk of bone loss);
• a muscle disorder such as myasthenia gravis; or
• an electrolyte imbalance (such as low levels of potassium in your blood).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using methylprednisolone.

Use Methacort 40 (Injectable) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• shortness of breath (even with mild exertion), swelling, rapid weight gain;
• severe depression, changes in personality, unusual thoughts or behavior;
• new or unusual pain in an arm or leg or in your back;
• severe pain in your upper stomach spreading to your back, nausea and vomiting;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• a seizure (convulsions); or
• low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Methylprednisolone can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

• weight gain (especially in your face or your upper back and torso);
• slow wound healing;
• muscle pain or weakness;
• thinning skin, increased sweating;
• stomach discomfort, bloating;
• headache; or
• changes in your menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not receive a "live" vaccine while using methylprednisolone. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using methylprednisolone.