Minocycline is a tetracycline antibiotic.

Minocycline topical (for the skin) is used to treat severe acne in adults and children at least 9 years old.

Minocycline topical is also used to treat rosacea in adults.

minocycline topical is not for use in treating a skin infection.

Minocycline topical may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Shake the foam canister well just before each use.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Minocycline topical is usually applied once per day, at least 1 hour before bedtime. Apply only a small amount of topical foam to affected skin areas.

Try to use the medicine at the same time each day.

Do not bathe or shower or swim for at least 1 hour after you have applied minocycline topical.

Store at room temperature away from moisture and heat. Do not keep this medicine in a refrigerator.

Minocycline topical foam is refrigerated at the pharmacy before you receive it. You may be instructed to continue storing the canister in a refrigerator at home, until you first start using the medicine. When you begin using a canister for the first time, allow it to reach room temperature before you apply the medicine. Once you start using a canister, keep storing it at room temperature for up to 90 days and then throw it away, even if there is still medicine left inside.

Minocycline topical foam is flammable. Do not use near high heat or open flame. Do not smoke until the medicine has completely dried on your skin.

Usual Adult Dose for Periodontitis:

Adult periodontitis:
1 mg applied subgingivally by an oral health care professional into the base of the affected periodontal pocket. The quantity of 1 mg unit dose packets required for treatment varies with the depth, severity, and number of lesions. During clinical trials, up to 121 unit dose containers of minocycline topical were applied to a single patient during a single treatment session. Additionally, patients were treated in up to 3 sessions occurring at 3 month intervals.

You should not use minocycline topical if you are allergic to minocycline or to similar antibiotics such as demeclocycline, doxycycline, or tetracycline.

Tell your doctor if you have ever had:

• liver disease;

• kidney disease;

• increased pressure inside your skull; or

• if you are currently having diarrhea or watery stools.

Tell your doctor if you are pregnant. Although it is not known whether minocycline applied to the skin is harmful to an unborn baby, taking minocycline by mouth during the second or third trimester of pregnancy may cause bone growth problems in the unborn baby, or permanent tooth discoloration later in life.

You should not breastfeed while using minocycline topical.

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

An overdose of minocycline topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not store it in the refrigerator.

Minocycline foam is flammable, keep it away from flames and extreme heat. Do not puncture or incinerate the container.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Unless your doctor tells you otherwise, continue your normal diet.

Avoid driving or hazardous activity until you know how minocycline topical will affect you. Your reactions could be impaired.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Minocycline topical could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid getting this medicine in your eyes, mouth, or vagina.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Serious side effects are unlikely when minocycline topical is applied to the skin, but can occur if the medicine is absorbed into your bloodstream.

Minocycline topical may cause serious side effects. Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

• severe dizziness;

• confusion, headache, vision problems, pain behind your eyes;

• fever, swollen glands, itching, joint pain, or not feeling well;

• discoloration of your skin, nails, eyes, mouth, gums, or teeth.

• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight.

Minocycline can affect growth in children, especially if used long term.

Common side effects of minocycline topical may include:

• diarrhea; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tell your doctor about all your other medicines, especially:

• isotretinoin;

• a blood thinner--warfarin, Coumadin, Jantoven; or

• a penicillin antibiotic--amoxicillin, ampicillin, nafcillin, oxacillin, Augmentin, Prevpac, and others.

This list is not complete. Other drugs may affect minocycline topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are using topical minocycline.

Minocycline topical may stain fabric.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.