Mobocertinib is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic) and cannot be removed with surgery, and whose disease has worsened while on or after chemotherapy with platinum.

Mobocertinib is used if your cancer has a specific genetic marker (an abnormal "EGFR" gene). Your doctor will test you for this gene.

Mobocertinib may also be used for purposes not listed in this medication guide.

Tell your doctor if you have:

• heart problems, including long QT syndrome;
• an electrolyte imbalance (such as low blood levels of sodium, potassium, calcium, or magnesium); or
• lung or breathing problems other than lung cancer.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Mobocertinib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 month for women and at least 1 week for men after your last dose. Tell your doctor right away if a pregnancy occurs.

Mobocertinib can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Mobocertinib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Use Mobocertinib Oral (Exkivity) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• new or worsening breathing problems or shortness of breath, cough, or fever;
• fast or pounding heartbeats, fluttering in your chest, swelling in your ankles or feet, chest pain, and sudden dizziness (like you might pass out); or
• diarrhea.

Common side effects may include:

• diarrhea, vomiting, nausea, decreased appetite;
• rash, dry skin, skin infection around nails;
• tiredness;
• mouth sores; or
• muscle or joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Grapefruit may interact with mobocertinib and cause side effects. Avoid consuming grapefruit products.