Nebivolol and valsartan is a combination medicine used in adults to treat high blood pressure (hypertension).

Nebivolol and valsartan may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to nebivolol or valsartan, or if you have:

• a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
• severe heart failure (that required you to be in the hospital or take certain medicines);
• very low heartbeats (severe bradycardia); or
• severe liver disease.

If you have diabetes, do not use nebivolol and valsartan with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking nebivolol and valsartan with aliskiren if you have kidney disease.

Tell your doctor if you have or have ever had:

• low blood pressure;
• heart problems;
• asthma or lung disease;
• diabetes;
• thyroid disorder;
• blood flow problems to your feet and legs (peripheral vascular disease);
• pheochromocytoma (tumor of the adrenal gland);
• a severe allergic reaction to any blood pressure medication;
• if you are on a low-salt diet;
• if you plan to have surgery with general anesthesia;
• liver disease; or
• kidney disease (or if you are on dialysis).

Do not use if you are pregnant. Stop using this medicine and tell your doctor right away if you become pregnant. Nebivolol and valsartan can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

Use Nebivolol And Valsartan (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• feeling like you might pass out;
• very slow heartbeats;
• low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery;
• heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• heart problems--swelling, rapid weight gain, feeling short of breath;
• kidney problems--swelling, urinating less, feeling tired or short of breath; or
• high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects may include:

• slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not take potassium supplements or use salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.