Nivolumab and relatlimab is used to treat people 12 years or older who weigh at least 88 lbs (40 kg) with a type of skin cancer called melanoma that has spread or cannot be removed by surgery.

Nivolumab and relatlimab may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• a nervous system problem, such as myasthenia gravis or Guillain-Barré syndrome;
• a immune system problem, such as Crohn's disease, ulcerative colitis, or lupus;
• received or plan to receive a stem cell transplant that uses donor stem cells; or
• received an organ transplant.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using nivolumab and relatlimab and for at least 5 months after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 5 months after your last dose.

Use Nivolumab And Relatlimab (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

• double or blurry vision;
• severe muscle pain, cramps, or weakness;
• confusion, sleep or memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness in your extremities;
• lung problems--new or worsening cough, shortness of breath, or chest pain;
• intestinal problems--diarrhea or more frequent bowel movements than usual, bloody or tarry stools, severe stomach pain or tenderness;
• liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• hormonal problems--headaches that will not go away or unusual headaches, sensitivity to light, eye problems, rapid heartbeat, increased sweating, extreme tiredness, weight gain or loss, feeling more hungry or thirsty than usual, urinating more often than usual, hair loss, feeling cold, constipation, deepened voice, dizziness, fainting, changes in mood or behavior;
• kidney problems--swelling in your ankles, loss of appetite, urinating less, blood in your urine;
• skin problems--rash, itching, skin blistering or peeling, sore or ulcers in mouth, nose, throat, or genital area;
• heart problems--new or worse chest pain, irregular heartbeat, shortness of breath, tiredness, swelling in your ankles; or
• low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

• muscle and bone pain;
• rash, itching;
• diarrhea;
• tiredness; or
• abnormal blood test results.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.