Desipramine is a tricyclic antidepressant that is used to treat symptoms of depression.

Desipramine may also be used for purposes not listed in this medication guide.

You should not use desipramine if you are allergic to it, or:

• if you have recently had a heart attack.

Do not use desipramine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Do not take an MAOI for at least 2 weeks after you stop taking desipramine.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

• bipolar disorder (manic-depression) or schizophrenia;
• mental illness or psychosis;
• liver disease;
• heart disease;
• a family history of sudden death related to a heart rhythm disorder;
• a heart attack, stroke, or seizures;
• a thyroid disorder;
• glaucoma; or
• problems with urination.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with desipramine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Desipramine is not approved for use by anyone younger than 18 years old.

Use Norpramin (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• easy bruising, unusual bleeding, purple or red spots under your skin;
• a light-headed feeling, like you might pass out;
• confusion, hallucinations, unusual thoughts or behavior;
• blurred vision, tunnel vision, eye pain or swelling, seeing halos around lights;
• new or worsening chest pain, pounding heartbeats or fluttering in your chest;
• sudden numbness or weakness, problems with vision, speech, or balance;
• fever, sore throat;
• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);
• painful or difficult urination;
• upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes);
• a seizure; or
• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

• increased blood pressure;
• tingly feeling, weakness, lack of coordination;
• dry mouth, loss of appetite, nausea, vomiting;
• breast swelling (in men or women); or
• weight gain or weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with desipramine.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid exposure to sunlight or tanning beds. Desipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.