Obinutuzumab is used in combination with another cancer medicine called chlorambucil to treat chronic lymphocytic leukemia.

Obinutuzumab is also used in combination with other cancer medicines to treat follicular lymphoma (a type of non-Hodgkin lymphoma), or to help delay the progression of this disease.

Obinutuzumab may also be used for purposes not listed in this medication guide.

You should not receive this medicine if you have ever had a severe allergic reaction to obinutuzumab, including a condition called serum sickness.

Tell your doctor if you have ever had:

• high blood pressure;
• hepatitis B or other liver problems;
• kidney disease;
• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
• if you have an active infection.

Do not use obinutuzumab if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

Do not breastfeed while using this medicine, and for at least 6 months after your last dose.

Use Obinutuzumab (Gazyva) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, rash; fever, joint pain; fast heartbeats, chest pain, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Obinutuzumab may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Some side effects may occur during the injection, or within 24 hours afterward. Tell your caregiver if you feel sudden warmth, redness, tingly feeling, feverish, chilled, light-headed, nauseated, or if you have headache, pounding in your neck or ears, tiredness, rash, dizziness, diarrhea, vomiting, chest discomfort, or trouble breathing.

Call your doctor at once if you have other side effects such as:

• easy bruising, unusual bleeding, purple or red spots under your skin;
• weakness, cough, diarrhea, burning when you urinate;
• right-sided upper stomach pain, loss of appetite, yellowing of your skin or eyes;
• dizziness, loss of balance or coordination;
• confusion, vision problems, problems with speech or walking;
• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or
• signs of tumor cell breakdown--tiredness, muscle cramps, nausea, vomiting, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• a reaction during or shortly after the injection;
• tiredness;
• low white blood cell counts;
• diarrhea, constipation;
• muscle or joint pain; or
• cold symptoms such as stuffy nose, sneezing, cough, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not receive a "live" vaccine while receiving obinutuzumab. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), or zoster (shingles).