Ioversol is a radiopaque contrast agent. Ioversol contains iodine, a substance that absorbs x-rays. Contrast agents are used to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on a CT scan or other radiologic (x-ray) examination.

Ioversol is used to help diagnose certain disorders of the heart, brain, and blood vessels.

Ioversol may also be used for purposes not listed in this medication guide.

You should not be treated with ioversol if you are allergic to it, or if you have:

• symptoms of an overactive thyroid.

Tell your doctor if you have ever had:

• any type of reaction to another contrast agent
• liver or kidney disease;
• a stroke, blood clot, or coronary artery disease (hardened arteries);
• a seizure;
• heart disease, high blood pressure, congestive heart failure;
• diabetes;
• homocystinuria;
• sickle cell anemia;
• asthma, hay fever, food allergies;
• multiple myeloma (bone cancer);
• pheochromocytoma (tumor of the adrenal gland);
• a thyroid disorder; or
• if you are dehydrated.

Tell your doctor if you are pregnant.

You should not breastfeed within 8 hours after receiving ioversol. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Use Optiray 350 (Injectable) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Some of the side effects of ioversol can occur up to 24 hours after you receive the medication.

Tell your caregivers or call your doctor at once if you have:

• trouble breathing;
• a light-headed feeling, like you might pass out;
• slow heartbeats;
• unexplained muscle pain, tenderness, or weakness;
• a skin rash;
• pain, bleeding, or skin changes where the injection was given;
• sudden numbness or weakness (especially on one side of the body), problems with vision or speech;
• chest pain or pressure, pain spreading to your jaw or shoulder; or
• kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath.

Side effects may be more likely in older adults.

Common side effect may include nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not allow yourself to become dehydrated during the first few days after receiving ioversol. Call your doctor if you have any vomiting or diarrhea during this time. Follow your doctor's instructions about the types and amount of fluids you should drink.