Acetaminophen is a pain reliever and fever reducer.

Magnesium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.

Pamabrom is a diuretic (water pill).

Acetaminophen, magnesium salicylate, and pamabrom is a combination medicine used to treat menstrual symptoms such as cramps, headache, backache, muscle aches, bloating, and fluid retention.

Acetaminophen, magnesium salicylate, and pamabrom may also be used for other purposes not listed in this medication guide.

You should not take this medication if you are allergic to acetaminophen (Tylenol), magnesium salicylate (Nuprin), pamabrom, aspirin or other NSAIDs.

Do not give this medication to a child or teenager with a fever, flu symptoms, or chicken pox. Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition in children.

Magnesium salicylate may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking acetaminophen, magnesium salicylate, and pamabrom, especially if you take this medicine for a long time, or:

• if you are age 60 or older;
• if you have a history of stomach ulcer or bleeding;
• if you drink more than 3 alcoholic beverages per day;
• if you take a blood thinner (warfarin, Coumadin), a steroid, or a diuretic ("water pill"); or
• if you also take any other NSAID, such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

• liver disease, cirrhosis, or history of alcoholism;
• heartburn or other stomach problems;
• high blood pressure, heart disease;
• kidney disease;
• gout;
• diabetes; or
• arthritis.

Magnesium salicylate may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. Do not take acetaminophen, magnesium salicylate, and pamabrom without telling your doctor if you are pregnant or plan to become pregnant during treatment.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Use Pamprin Cramp Formula (Apap Magnesium Salicylate Pamabrom) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• severe stomach pain;
• a light-headed feeling, like you might pass out;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• any redness or swelling; or
• ringing in your ears or hearing problems.

Common side effects may include:

• heartburn; or
• upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.