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Home > Drugs > Proton pump inhibitors > Prilosec
Proton pump inhibitors

Prilosec

https://themeditary.com/drug/prilosec-604.html
Medically Reviewed by Sophia Entringer, PharmD TheMediTary.Com | Reviewed: Jul 11, 2023  Additional Content by TheMediTary.Com

Generic name: omeprazole [ oh-mep-ra-zol ]

Drug class: Proton pump inhibitors

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Prilosec otc, Omeprazole, Omeprazole + syrspend sf alka, Good sense omeprazole

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
  • Prilosec (Omeprazole [ oh-mep-ra-zol ])-607 PRILOSEC 20-20 mg-Purple-Capsule-shape Prilosec 20 mg (607 PRILOSEC 20)
  • Prilosec (Omeprazole [ oh-mep-ra-zol ])-606 PRILOSEC 10-10 mg-Pink & Purple-Capsule-shape Prilosec 10 mg (606 PRILOSEC 10)
  • Prilosec (Omeprazole [ oh-mep-ra-zol ])-743 PRILOSEC 40-40 mg-Pink / Purple-Capsule-shape Prilosec 40 mg (743 PRILOSEC 40)
  • Prilosec (Omeprazole [ oh-mep-ra-zol ])-742 PRILOSEC 20-20 mg-Purple-Capsule-shape Prilosec 20 mg (742 PRILOSEC 20)
  • View all images

What is Prilosec?

Prilosec is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Prilosec is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Prilosec may also be given together with antibiotics to treat gastric ulcer caused by infection with Helicobacter pylori (H. pylori).

Over-the-counter Prilosec OTC is used in adults to help control heartburn that occurs 2 or more days per week. Prilosec OTC must be taken as a course for 14 days in a row.

Warnings

Prilosec is not to be used for the immediate relief of heartburn symptoms.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency mdical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Prilosec may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

Prilosec OTC (over-the-counter) should be taken for no longer than 14 days in a row. Allow at least 4 months to pass before you start another 14-day treatment.

How should I use Prilosec

Take Prilosec exactly as directed on the label, or as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Use Prilosec OTC (over-the-counter) exactly as directed on the label, or as prescribed by your doctor.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

You must dissolve Prilosec powder in a small amount of water. This mixture can either be swallowed or given through a nasogastric (NG) feeding tube using a catheter-tipped syringe.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

OTC Prilosec should be taken for only 14 days in a row. It may take 1 to 4 days before your symptoms improve. Allow at least 4 months to pass before you start a new 14-day course of treatment.

Call your doctor if your symptoms do not improve, or if they get worse.

Some conditions are treated with a combination of Prilosec and antibiotics. Use all medications as directed.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Prilosec.

Store at room temperature away from moisture and heat.

Detailed Prilosec dosage information
Prilosec Dosage information (more detail)

Before Taking

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel sweaty or light-headed.

You should not use Prilosec if you are allergic to omeprazole, or if:

  • you are also allergic to medicines like omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;

  • you had breathing problems, kidney problems, or a severe allergic reaction after taking omeprazole in the past; or

  • you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).

Ask a doctor or pharmacist if this medicine is safe to use if you have:

  • trouble or pain with swallowing;

  • bloody or black stools, vomit that looks like blood or coffee grounds;

  • heartburn that has lasted for over 3 months;

  • frequent chest pain, heartburn with wheezing;

  • unexplained weight loss;

  • nausea or vomiting, stomach pain;

  • liver disease;

  • low levels of magnesium in your blood; or

  • osteoporosis or low bone mineral density (osteopenia).

You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give Prilosec to a child without medical advice.

Prilosec pregnancy and breastfeeding warnings (more detail)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Prilosec?

This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Prilosec side effects

Get emergency medical help if you have signs of an allergic reaction to Prilosec: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Prilosec and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • new or unusual pain in your wrist, thigh, hip, or back;

  • seizure (convulsions);

  • kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;

  • low magnesium - dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or

  • new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking Prilosec long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use omeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common Prilosec side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat (especially in children);

  • fever (especially in children);

  • stomach pain, gas;

  • nausea, vomiting, diarrhea; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Prilosec Side Effects

What other drugs will affect Prilosec?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect omeprazole, especially:

  • digoxin;

  • clopidogrel;

  • methotrexate;

  • St. John's wort;

  • a diuretic or "water pill"; or

  • an antibiotic - amoxicillin, clarithromycin, rifampin.

This list is not complete and many Other drugs may interact with omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What to Expect

Once you start taking Prilosec, you should begin feeling better within two to three days. It can take up to four weeks for prescription omeprazole to work completely.

Tell your doctor if you don’t notice any changes after about two weeks. Your physician may want to switch you to a different medicine.

OTC Prilosec should be taken for 14 days in a row. Don’t take it for longer than two weeks without checking with a doctor.

Additional Dosage Information

Your dosage will depend on your medical condition and the formulation of Prilosec you use.

Dosages are typically lower for children and individuals with liver problems.

Secondary Uses

Prilosec is sometimes also used off-label for:

  • Barrett’s esophagus
  • Infants with GERD
  • Other types of ulcers
  • Preventing aspiration before surgery

Talk to your doctor before using Prilosec to treat any condition that it’s not prescribed for.

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More about Prilosec (Omeprazole [ oh-mep-ra-zol ])

Dosage information
Prilosec Side Effects
Patient tips
During pregnancy
Prilosec Prescribing Information
Drug images
Side effects
Drug class: Proton pump inhibitors

Patient resources

Prilosec Delayed-Release Capsules
Prilosec (Powder for Oral Suspension)

Related treatment guides

GERD
Duodenal Ulcer
Erosive Esophagitis
Barrett's Esophagus
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
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