You should not use this medicine if you are allergic to prochlorperazine or other phenothiazines (such as chlorpromazine, fluphenazine, perphenazine, promethazine, thioridazine, or trifluoperazine).
Do not use prochlorperazine if you have recently used large amounts of alcohol or medicine that makes you sleepy.
Prochlorperazine is not approved for use by anyone younger than 2 years old or weighing less than 20 pounds. Talk with your doctor before giving prochlorperazine to a child or teenager with a fever, flu symptoms, vomiting, or diarrhea.
Do not give this medicine to a child before or after a surgery.
Prochlorperazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
Tell your doctor if you have ever had:
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heart disease;
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seizures, or a brain tumor;
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low white blood cell (WBC) counts;
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glaucoma;
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pheochromocytoma (tumor of the adrenal gland);
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low blood pressure;
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breast cancer; or
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chemotherapy.
Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using prochlorperazine.
Tell your doctor if you are pregnant or you get pregnant. Taking antipsychotic medication during the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.