Generic name: quinapril [ kwin-a-pril ]
Drug class: Angiotensin Converting Enzyme Inhibitors
Dosage form: oral tablet (10 mg; 20 mg; 40 mg; 5 mg)
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Accupril
What is Quinapril?
Quinapril is used in adults alone or in combination with other medications to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.
Quinapril is also used in adults together with other medications to treat heart failure.
Quinapril may also be used for purposes not listed in this medication guide.
Warnings
Do not use if you are pregnant. Stop using quinapril and tell your doctor right away if you become pregnant.
You should not use quinapril if you have ever had angioedema. Do not take quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use quinapril together with any medication that contains aliskiren (a blood pressure medicine).
How should I take Quinapril
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
Tell your doctor if you have a planned surgery.
If you have high blood pressure, keep using quinapril even if you feel well. High blood pressure often has no symptoms.
Store tightly closed at room temperature, away from moisture and heat.
Dosing information
Usual Adult Dose for Hypertension:
Initial dose: 10 or 20 mg orally once a day in patients not on diuretics
Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses
Use:
-Treatment of hypertension
Usual Adult Dose for Congestive Heart Failure:
Initial dose: 5 mg orally twice a day
Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses
Comments:
-This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses.
-If the initial dosage is well tolerated, patients should then be titrated at weekly intervals until an effective dose.
Use:
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Usual Geriatric Dose for Congestive Heart Failure:
10 mg orally once a day
Comments: Dose should be titrated the same way as for other adult patients.
Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Usual Geriatric Dose for Hypertension:
10 mg orally once a day
Comments: Dose should be titrated the same way as for other adult patients.
Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Before Taking
You should not use quinapril if you are allergic to it, or if:
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have a history of angioedema; or
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you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, ramipril, or trandolapril.
Do not take quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use quinapril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking quinapril with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
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a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
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heart problems;
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low blood pressure;
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high blood levels of potassium (hyperkalemia);
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if you are on a low-salt diet;
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low white blood cell counts;
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diabetes;
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kidney disease (or if you are on dialysis); or
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liver disease.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Quinapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Ask a doctor if it is safe to breastfeed while using this medicine.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light and excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What special dietary instructions should I follow?
Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
What should I avoid while using Quinapril?
Do not take potassium supplements or use salt substitutes, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Avoid strenuous exercise if you are being treated for heart failure. Ask your doctor about your risk.
Quinapril side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Quinapril may cause serious side effects. Call your doctor at once if you have:
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chest pain, fast, slow, or uneven heart rate;
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a light-headed feeling, like you might pass out;
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heart problems--swelling, rapid weight gain, feeling short of breath;
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kidney problems--swelling, urinating less, feeling tired or short of breath;
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liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), abnormal liver function tests;
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signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or
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high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.
Common side effects of quinapril may include:
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headache;
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nausea, vomiting, stomach pain;
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cough; or
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dizziness, tiredness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See more: Quinapril Side EffectsWhat other drugs will affect Quinapril?
Tell your doctor about all your other medicines, especially:
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lithium;
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a diuretic or "water pill";
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gold injections to treat arthritis;
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temsirolimus, sirolimus, or everolimus; or
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NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to quinapril. Your doctor may order certain lab tests to check your body's response to quinapril.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Combination Products
- Accuretic® (containing Quinapril, Hydrochlorothiazide)
- Quinaretic® (containing Quinapril, Hydrochlorothiazide)