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Home > Drugs > Antianginal agents > Ranolazine
Antianginal agents

Ranolazine

https://themeditary.com/drug/ranolazine-5447.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: ranolazine [ ra-noe-la-zeen ]

Drug class: Antianginal agents

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Ranexa, Aspruzyo sprinkle

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Ranolazine (Ranolazine [ ra-noe-la-zeen ])-LU L31-500 mg-Orange-Oval Ranolazine 500 mg (LU L31)
  • Ranolazine (Ranolazine [ ra-noe-la-zeen ])-LU L32-1000 mg-Yellow-Oval Ranolazine 1000 mg (LU L32)
  • Ranolazine (Ranolazine [ ra-noe-la-zeen ])-Logo 418-500 mg-Gray-Oval Ranolazine 500 mg (Logo 418)
  • Ranolazine (Ranolazine [ ra-noe-la-zeen ])-Logo 419-1000 mg-Pink-Oval Ranolazine 1000 mg (Logo 419)
  • View all images

What is Ranolazine?

Ranolazine is used in adults to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.

Warnings

You should not take ranolazine if you have cirrhosis of the liver.

Tell your doctor about all your other medicines. Some drugs should not be used with ranolazine.

How should I take Ranolazine

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take ranolazine tablets with or without food.

Open the pack of ranolazine granules and mix the medicine with a tablespoon of soft food such as applesauce or yogurt. Swallow the mixture right away without crushing or chewing.

Ranolazine granules can also be given through a feeding tube. Ask your doctor or pharmacist if you do not understand these instructions.

Swallow the tablet whole and do not crush, chew, or break it.

Chronic angina is often treated with a combination of drugs. Do not change your dose or dosing schedule without your doctor's advice.

Call your doctor if your symptoms do not improve, or if they get worse.

You may need medical tests to check your heart and kidney function.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Angina Pectoris:

500 mg orally twice a day; increase to 1000 mg orally twice a day as needed

Maximum dose: 1000 mg orally twice a day

Use: Treatment of chronic angina

Detailed Ranolazine dosage information
Ranolazine Dosage information (more detail)

Before Taking

You should not take ranolazine if you are allergic to it, or if you have:

  • cirrhosis of the liver.

Some drugs should not be used with ranolazine. Your treatment plan may change if you also use:

  • clarithromycin;

  • nefazodone;

  • St. John's wort;

  • antifungal medicine--itraconazole, ketoconazole;

  • HIV or AIDS medicine--indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;

  • seizure medicine--carbamazepine, phenobarbital, phenytoin; or

  • tuberculosis medicine--rifabutin, rifampin, rifapentine.

Tell your doctor if you have ever had:

  • long QT syndrome (in you or a family member);

  • liver disease; or

  • kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms include nausea, vomiting, numbness or tingling, low blood pressure, dizziness, irregular heartbeats, trouble speaking, double vision, hallucinations, confusion, uncontrolled shaking, or fainting.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What special dietary instructions should I follow?

Do not drink grapefruit juice or eat grapefruit products while taking this medication.

What should I avoid while using Ranolazine?

Avoid driving or hazardous activity until you know how ranolazine will affect you. Your reactions could be impaired.

Avoid drinking alcohol. Drinking alcohol with ranolazine granules can cause side effects.

Grapefruit may interact with ranolazine and lead to unwanted side effects. Avoid the use of grapefruit products.

Ranolazine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ranolazine may cause serious side effects. Call your doctor at once if you have:

  • a light-headed feeling;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or

  • kidney problems--swelling, urinating less, feeling tired or short of breath.

Common side effects of ranolazine may include:

  • nausea, constipation;

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Ranolazine Side Effects

What other drugs will affect Ranolazine?

Tell your doctor about all your current medicines. Many drugs can affect ranolazine, especially:

  • any other medicine to treat heart disease;

  • an antibiotic or antifungal medicine;

  • oral diabetes medicine;

  • medicine to prevent organ transplant rejection;

  • medicine to treat a mental illness; or

  • medicine to treat or prevent nausea and vomiting caused by chemotherapy or radiation.

This list is not complete and many other drugs may affect ranolazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Ranolazine (Ranolazine [ ra-noe-la-zeen ])

Dosage information
Ranolazine Side Effects
During pregnancy
Drug images
Side effects
Drug class: Antianginal agents

Related treatment guides

Angina
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