Rocklatan (for the eyes) is a combination medicine used to treat open-angle glaucoma and other causes of high pressure inside the eye.

Rocklatan may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

The usual dose of this medicine is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully.

Tell your doctor right away if you have an eye injury or eye infection, or if you plan to have eye surgery.

Do not use while wearing soft contact lenses. A preservative in this medicine could permanently stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses.

Wash your hands before using eye medication.

To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your eyes for 1 or 2 minutes.

Use only the number of drops your doctor has prescribed.

Wait at least 5 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Store in the refrigerator. Protect from light and do not freeze. Keep the bottle tightly closed when not in use.

You should not use Rocklatan if you are allergic to latanoprost or netarsudil.

Tell your doctor if you have ever had:

• swelling or an infection in your eye;

• damage to the surface of your eye (also called the cornea);

• herpes infection of the eyes; or

• eye surgery or injury affecting the lens of your eye.

Latanoprost can cause a gradual change in the color of your eyes or eyelids and lashes, usually an increase in brown pigment. You may also notice increased growth or thickness of your eyelashes. These changes occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Rocklatan is not approved for use by anyone younger than 18 years old.

Tell your doctor if you are pregnant or breast-feeding.

Skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

An overdose of Rocklatan is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Avoid using too much of Rocklatan, which can actually make it less effective in lowering the pressure inside the eye.

Do not use other eye medications unless your doctor tells you to.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Latanoprost may cause serious side effects. Stop using latanoprost and call your doctor at once if you have:

• eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);

• red, swollen, or itchy eyelids;

• vision changes; or

• severe burning, stinging, or irritation after using Rocklatan.

Common side effects of Rocklatan may include:

• eye pain after using the drops;

• eye redness; or

• changes to the surface of your eye that can be seen on an eye exam but are not likely to affect your vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.