Doxorubicin is used to treat different types of cancers that affect the breast, bladder, kidneys, ovaries, thyroid, stomach, lungs, bones, nerve tissues, joints, and soft tissues. Doxorubicin is also used to treat Hodgkin lymphoma, non-Hodgkin lymphoma, and certain types of leukemia.

Doxorubicin may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to doxorubicin or similar medications (doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxantrone), or if you have:

• very low blood cell counts caused by chemotherapy you received in the past;
• severe liver disease;
• severe heart problems; or
• if you have recently had a heart attack.

Tell your doctor if you have ever had:

• severe liver disease;
• heart disease or heart failure; or
• radiation treatment to your chest.

Tell your doctor about all other cancer medicines or radiation treatments you have received in the past.

Using doxorubicin may increase your risk of developing a bone marrow disease or other types of leukemia later in life. Ask your doctor about your specific risk.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Doxorubicin can harm an unborn baby or cause birth defects if the mother or father is using this medicine.

Keep using birth control for at least 6 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using doxorubicin.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because doxorubicin can harm an unborn baby.

Doxorubicin may also cause early menopause, depending on your age when you receive this medicine. Ask your doctor about this risk.

You should not breastfeed while you are using doxorubicin.

Use Rubex (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

• pain, blisters, or skin sores where the injection was given;
• missed menstrual periods;
• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
• low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
• signs of heart problems--fast heartbeats, shortness of breath (even with mild exertion), feeling very weak or tired, swelling in your ankles or feet.

Doxorubicin may cause your urine to turn a reddish-orange color. This side effect is usually not harmful.

Common side effects may include:

• nausea, vomiting; or
• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.